Design, evaluation and structure—Activity relationship studies of the AChE reactivators against organophosphorus pesticides
Organophosphate pesticides (OPPs; eg chlorpyrifos, diazinon, paraoxon) are a wide and
heterogeneous group of organophosphorus compounds. Their biological activity of …
heterogeneous group of organophosphorus compounds. Their biological activity of …
Recent developments on oximes to improve the blood brain barrier penetration for the treatment of organophosphorus poisoning: a review
MNF Norrrahim, MAIA Razak, NAA Shah, H Kasim… - RSC …, 2020 - pubs.rsc.org
Organophosphorus (OP) compounds are highly toxic synthetic compounds which have been
used as pesticides and developed as warfare nerve agents. They represent a threat to both …
used as pesticides and developed as warfare nerve agents. They represent a threat to both …
Pyridinium Oximes with Ortho-Positioned Chlorine Moiety Exhibit Improved Physicochemical Properties and Efficient Reactivation of Human Acetylcholinesterase …
T Zorbaz, D Malinak, N Maraković… - Journal of medicinal …, 2018 - ACS Publications
Six chlorinated bispyridinium mono-oximes, analogous to potent charged reactivators K027,
K048, and K203, were synthesized with the aim of improving lipophilicity and reducing the p …
K048, and K203, were synthesized with the aim of improving lipophilicity and reducing the p …
Potent 3‐Hydroxy‐2‐Pyridine Aldoxime Reactivators of Organophosphate‐Inhibited Cholinesterases with Predicted Blood–Brain Barrier Penetration
T Zorbaz, A Braïki, N Maraković… - … A European Journal, 2018 - Wiley Online Library
A new series of 3‐hydroxy‐2‐pyridine aldoxime compounds have been designed,
synthesised and tested in vitro, in silico, and ex vivo as reactivators of human …
synthesised and tested in vitro, in silico, and ex vivo as reactivators of human …
A comprehensive evaluation of the efficacy of leading oxime therapies in guinea pigs exposed to organophosphorus chemical warfare agents or pesticides
CM Wilhelm, TH Snider, MC Babin, DA Jett… - Toxicology and applied …, 2014 - Elsevier
The currently fielded pre-hospital therapeutic regimen for the treatment of
organophosphorus (OP) poisoning in the United States (US) is the administration of atropine …
organophosphorus (OP) poisoning in the United States (US) is the administration of atropine …
Evaluation of oxime K203 as antidote in tabun poisoning
Z Kovarik, A Lucić Vrdoljak, S Berend… - Arhiv za higijenu rada i …, 2009 - hrcak.srce.hr
Sažetak We studied bispyridinium oxime K203 [(E)-1-(4-carbamoylpyridinium)-4-(4-
hydroxyimino methylpyridinium)-but-2-ene dibromide] with tabun-inhibited human …
hydroxyimino methylpyridinium)-but-2-ene dibromide] with tabun-inhibited human …
Comparative protective effects of HI-6 and MMB-4 against organophosphorous nerve agent poisoning
PM Lundy, MG Hamilton, TW Sawyer, J Mikler - Toxicology, 2011 - Elsevier
Abstract The oximes pralidoxime (2-PAM), its dimethanesulphonate salt derivative P2S, and
obidoxime (toxogonin) are currently licensed and fielded for the treatment of chemical …
obidoxime (toxogonin) are currently licensed and fielded for the treatment of chemical …
Reversal of Tabun Toxicity Enabled by a Triazole‐Annulated Oxime Library—Reactivators of Acetylcholinesterase
Z Kovarik, J Kalisiak, NM Hrvat… - … A European Journal, 2019 - Wiley Online Library
Acetylcholinesterase (AChE), an enzyme that degrades the neurotransmitter acetylcholine,
when covalently inhibited by organophosphorus compounds (OPs), such as nerve agents …
when covalently inhibited by organophosphorus compounds (OPs), such as nerve agents …
Design and synthesis of N-substituted-2-hydroxyiminoacetamides and interactions with cholinesterases
N Maraković, A Knežević, V Vinković, Z Kovarik… - Chemico-biological …, 2016 - Elsevier
Within this study, we designed and synthesized four new oxime compounds of the N-
substituted 2-hydroxyiminoacetamide structure and evaluated their interactions with …
substituted 2-hydroxyiminoacetamide structure and evaluated their interactions with …
The experimental oxime K027—a promising protector from organophosphate pesticide poisoning. A review comparing K027, K048, pralidoxime, and obidoxime
DE Lorke, GA Petroianu - Frontiers in neuroscience, 2019 - frontiersin.org
Poisoning with organophosphorus compounds (OPCs) is a major problem worldwide.
Standard therapy with atropine and established oxime-type enzyme reactivators …
Standard therapy with atropine and established oxime-type enzyme reactivators …