Regulated cell death (RCD) in cancer: key pathways and targeted therapies
F Peng, M Liao, R Qin, S Zhu, C Peng, L Fu… - Signal transduction and …, 2022 - nature.com
Regulated cell death (RCD), also well-known as programmed cell death (PCD), refers to the
form of cell death that can be regulated by a variety of biomacromolecules, which is …
form of cell death that can be regulated by a variety of biomacromolecules, which is …
Neuronal death mechanisms and therapeutic strategy in ischemic stroke
R Mao, N Zong, Y Hu, Y Chen, Y Xu - Neuroscience bulletin, 2022 - Springer
Ischemic stroke caused by intracranial vascular occlusion has become increasingly
prevalent with considerable mortality and disability, which gravely burdens the global …
prevalent with considerable mortality and disability, which gravely burdens the global …
[HTML][HTML] PARPs in lipid metabolism and related diseases
PARPs and tankyrases (TNKS) represent a family of 17 proteins. PARPs and tankyrases
were originally identified as DNA repair factors, nevertheless, recent advances have shed …
were originally identified as DNA repair factors, nevertheless, recent advances have shed …
A data-driven drug repositioning framework discovered a potential therapeutic agent targeting COVID-19
The global spread of SARS-CoV-2 requires an urgent need to find effective therapeutics for
the treatment of COVID-19. We developed a data-driven drug repositioning framework …
the treatment of COVID-19. We developed a data-driven drug repositioning framework …
Differences in PARP inhibitors for the treatment of ovarian cancer: mechanisms of action, pharmacology, safety, and efficacy
G Valabrega, G Scotto, V Tuninetti, A Pani… - International journal of …, 2021 - mdpi.com
Poly (ADP-ribose) polymerases (PARP) are proteins responsible for DNA damage detection
and signal transduction. PARP inhibitors (PARPi) are able to interact with the binding site for …
and signal transduction. PARP inhibitors (PARPi) are able to interact with the binding site for …
Possible adverse effects of high-dose nicotinamide: mechanisms and safety assessment
ES Hwang, SB Song - Biomolecules, 2020 - mdpi.com
Nicotinamide (NAM) at doses far above those recommended for vitamins is suggested to be
effective against a wide spectrum of diseases and conditions, including neurological …
effective against a wide spectrum of diseases and conditions, including neurological …
An integrative drug repositioning framework discovered a potential therapeutic agent targeting COVID-19
The global spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
requires an urgent need to find effective therapeutics for the treatment of coronavirus …
requires an urgent need to find effective therapeutics for the treatment of coronavirus …
The potential of PARP inhibitors in targeted cancer therapy and immunotherapy
J Hunia, K Gawalski, A Szredzka… - Frontiers in molecular …, 2022 - frontiersin.org
DNA damage response (DDR) deficiencies result in genome instability, which is one of the
hallmarks of cancer. Poly (ADP-ribose) polymerase (PARP) enzymes take part in various …
hallmarks of cancer. Poly (ADP-ribose) polymerase (PARP) enzymes take part in various …
[HTML][HTML] PARP1: Structural insights and pharmacological targets for inhibition
Abstract Poly (ADP-ribose) polymerase 1 (PARP1, also known as ADPRT1) is a
multifunctional human ADP-ribosyltransferase. It plays a role in multiple DNA repair …
multifunctional human ADP-ribosyltransferase. It plays a role in multiple DNA repair …
Why structure and chain length matter: on the biological significance underlying the structural heterogeneity of poly (ADP-ribose)
JM Reber, A Mangerich - Nucleic Acids Research, 2021 - academic.oup.com
Abstract Poly (ADP-ribosyl) ation (PARylation) is a multifaceted post-translational
modification, carried out by poly (ADP-ribosyl) transferases (poly-ARTs, PARPs), which play …
modification, carried out by poly (ADP-ribosyl) transferases (poly-ARTs, PARPs), which play …