Environmental chemicals, breast cancer progression and drug resistance

M Koual, C Tomkiewicz, G Cano-Sancho… - Environmental …, 2020 - Springer
Breast cancer (BC) is one of the most common causes of cancer in the world and the second
leading cause of cancer deaths among women. Mortality is associated mainly with the …

Betulin and its derivatives as novel compounds with different pharmacological effects

S Amiri, S Dastghaib, M Ahmadi, P Mehrbod… - Biotechnology …, 2020 - Elsevier
Betulin (B) and Betulinic acid (BA) are natural pentacyclic lupane-structure triterpenoids
which possess a wide range of pharmacological activities. Recent evidence indicates that B …

Aryl hydrocarbon receptor-induced signals up-regulate IL-22 production and inhibit inflammation in the gastrointestinal tract

I Monteleone, A Rizzo, M Sarra, G Sica, P Sileri… - Gastroenterology, 2011 - Elsevier
BACKGROUND & AIMS: The pathogenesis of inflammatory bowel disease (IBD) is believed
to involve an altered balance between effector and regulatory T cells. Aryl hydrocarbon …

[HTML][HTML] The exposome and liver disease-how environmental factors affect liver health

R Barouki, M Samson, EB Blanc, M Colombo… - Journal of …, 2023 - Elsevier
Since the initial development of the exposome concept, much effort has been devoted to the
characterisation of the exposome through analytical, epidemiological, and toxicological …

Phytochemicals targeting estrogen receptors: beneficial rather than adverse effects?

S Lecomte, F Demay, F Ferrière, F Pakdel - International Journal of …, 2017 - mdpi.com
In mammals, the effects of estrogen are mainly mediated by two different estrogen receptors,
ERα and ERβ. These proteins are members of the nuclear receptor family, characterized by …

Role of aryl hydrocarbon receptor activation in inflammatory chronic skin diseases

M Napolitano, G Fabbrocini, F Martora, V Picone… - Cells, 2021 - mdpi.com
Aryl Hydrocarbon Receptor (AhR) is an evolutionary transcription factor which acts as a
crucial sensor of different exogenous and endogenous molecules Recent data indicate that …

The aryl hydrocarbon receptor cross-talks with multiple signal transduction pathways

A Puga, C Ma, JL Marlowe - Biochemical pharmacology, 2009 - Elsevier
Exposure to toxic polycyclic aromatic hydrocarbons raises a number of toxic and
carcinogenic responses in experimental animals and humans mediated for the most part by …

Role of the aryl hydrocarbon receptor in carcinogenesis and potential as a drug target

S Safe, SO Lee, UH Jin - Toxicological Sciences, 2013 - academic.oup.com
The aryl hydrocarbon receptor (AHR) is highly expressed in multiple organs and tissues,
and there is increasing evidence that the AHR plays an important role in cellular …

The aryl hydrocarbon receptor and the nervous system

L Juricek, X Coumoul - International journal of molecular sciences, 2018 - mdpi.com
The aryl hydrocarbon receptor (or AhR) is a cytoplasmic receptor of pollutants. It translocates
into the nucleus upon binding to its ligands, and forms a heterodimer with ARNT (AhR …

Insight into the physiological and pathological roles of the aryl hydrocarbon receptor pathway in glucose homeostasis, insulin resistance, and diabetes development

TS Sayed, ZH Maayah, HA Zeidan, A Agouni… - Cellular & Molecular …, 2022 - Springer
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcriptional factor that mediates
the toxicities of several environmental pollutants. Decades of research have been carried …