Oxidative stress in the pathophysiology of type 2 diabetes and related complications: Current therapeutics strategies and future perspectives

JS Bhatti, A Sehrawat, J Mishra, IS Sidhu… - Free Radical Biology …, 2022 - Elsevier
Abstract Type 2 diabetes (T2DM) is a persistent metabolic disorder rising rapidly worldwide.
It is characterized by pancreatic insulin resistance and β-cell dysfunction. Hyperglycemia …

An overview of Nrf2 signaling pathway and its role in inflammation

S Saha, B Buttari, E Panieri, E Profumo, L Saso - Molecules, 2020 - mdpi.com
Inflammation is a key driver in many pathological conditions such as allergy, cancer,
Alzheimer's disease, and many others, and the current state of available drugs prompted …

Nrf2-mediated anti-inflammatory polarization of macrophages as therapeutic targets for osteoarthritis

L Wang, C He - Frontiers in immunology, 2022 - frontiersin.org
Macrophages are the most abundant immune cells within the synovial joints, and also the
main innate immune effector cells triggering the initial inflammatory responses in the …

Quercetin as an agent for protecting the bone: a review of the current evidence

SK Wong, KY Chin, S Ima-Nirwana - International journal of molecular …, 2020 - mdpi.com
Quercetin is a flavonoid abundantly found in fruits and vegetables. It possesses a wide
spectrum of biological activities, thus suggesting a role in disease prevention and health …

Dimethyl fumarate improves cognitive deficits in chronic cerebral hypoperfusion rats by alleviating inflammation, oxidative stress, and ferroptosis via NRF2/ARE/NF-κB …

N Yan, Z Xu, C Qu, JJ Zhang - International Immunopharmacology, 2021 - Elsevier
Cerebrovascular disease and its risk factors cause persistent decrease of cerebral blood
flow, chronic cerebral hypoperfusion (CCH) is the major foundation of vascular cognitive …

[HTML][HTML] Chronic hyperglycemia mediated physiological alteration and metabolic distortion leads to organ dysfunction, infection, cancer progression and other …

B Giri, S Dey, T Das, M Sarkar, J Banerjee… - Biomedicine & …, 2018 - Elsevier
Chronic exposure of glucose rich environment creates several physiological and
pathophysiological changes. There are several pathways by which hyperglycemia …

Dissecting molecular cross-talk between Nrf2 and NF-κB response pathways

JD Wardyn, AH Ponsford… - Biochemical society …, 2015 - portlandpress.com
In most tissues, cells are exposed to frequent changes in levels of oxidative stress and
inflammation. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and nuclear factor-κB (NF-κB) …

ROS-induced hepatotoxicity under cypermethrin: involvement of the crosstalk between Nrf2/Keap1 and NF-κB/iκB-α pathways regulated by proteasome

H Zhao, Y Wang, Y Liu, K Yin, D Wang… - … science & technology, 2021 - ACS Publications
Cypermethrin (CMN) is a man-made insecticide, and its abuse has led to potential adverse
effects, particularly in sensitive populations such as aquatic organisms. The present study …

NF-κβ: a potential target in the management of vascular complications of diabetes

SV Suryavanshi, YA Kulkarni - Frontiers in pharmacology, 2017 - frontiersin.org
Diabetes is a metabolic disorder affecting large percentage of population worldwide. NF-κβ
plays key role in pathogenesis of vascular complications of diabetes. Persistent …

Biochemical and cellular basis of oxidative stress: implications for disease onset

K Aramouni, R Assaf, A Shaito… - Journal of Cellular …, 2023 - Wiley Online Library
Cellular oxidation–reduction (redox) systems, which encompass pro‐and antioxidant
molecules, are integral components of a plethora of essential cellular processes. Any …