Microglia are the main immune cells in the brain, playing a role in both physiological and
pathological conditions. Microglial involvement in neurodegenerative diseases is well …

Although the first description of a lysosomal storage disorder was that of Tay‐Sachs disease
in 1881, the lysosome was not discovered until 1955, by Christian De Duve. The first …

Peripherally derived macrophages infiltrate the brain after bone marrow transplantation and
during central nervous system (CNS) inflammation. It was initially suggested that these …

We tested the hypothesis that bone marrow stromal cells (MSCs) transplanted into the
ischemic boundary zone, survive, differentiate and improve functional recovery after middle …

Sandhoff disease is a lysosomal storage disorder characterized by the absence of β-
hexosaminidase and storage of GM2 ganglioside and related glycolipids in the central …

To measure effect of bone marrow stromal cells (MSCs) administered iv on rats subjected to
traumatic brain injury (TBI), we injected MSCs labeled by BrdU into the tail vein 24 h after …

Lysosomal storage diseases (LSDs) comprise a diverse group of monogenetic disorders
with complex clinical phenotypes that include both systemic and central nervous system …

To determine the kinetics of tissue macrophage and microglial engraftment after bone
marrow (BM) transplantation, we have developed a model using the ROSA 26 mouse …

Over 400 patients with lysosomal and peroxisomal storage diseases have received
hematopoietic stem cell transplantation from normal donors. Without treatment, all of these …

Alpha-mannosidosis is an inherited lysosomal storage disorder characterized by immune
deficiency, facial and skeletal abnormalities, hearing impairment, and intellectual disability. It …