Structures and metal-ion-binding properties of the Ca2+-binding helix–loop–helix EF-hand motifs
JL Gifford, MP Walsh, HJ Vogel - Biochemical Journal, 2007 - portlandpress.com
The 'EF-hand'Ca2+-binding motif plays an essential role in eukaryotic cellular signalling,
and the proteins containing this motif constitute a large and functionally diverse family. The …
and the proteins containing this motif constitute a large and functionally diverse family. The …
Allostery: an illustrated definition for the 'second secret of life'
AW Fenton - Trends in biochemical sciences, 2008 - cell.com
Although allosteric regulation is the 'second secret of life', the molecular mechanisms that
give rise to allostery currently elude understanding. In my opinion, experimental progress is …
give rise to allostery currently elude understanding. In my opinion, experimental progress is …
[HTML][HTML] Calcium binding to calmodulin mutants monitored by domain-specific intrinsic phenylalanine and tyrosine fluorescence
WS VanScyoc, BR Sorensen, E Rusinova, WR Laws… - Biophysical journal, 2002 - cell.com
Cooperative calcium binding to the two homologous domains of calmodulin (CaM) induces
conformational changes that regulate its association with and activation of numerous cellular …
conformational changes that regulate its association with and activation of numerous cellular …
Pump‐probe molecular dynamics as a tool for studying protein motion and long range coupling
K Sharp, JJ Skinner - Proteins: Structure, Function, and …, 2006 - Wiley Online Library
A new method for analyzing the dynamics of proteins is developed and tested. The method,
pump‐probe molecular dynamics, excites selected atoms or residues with a set of oscillating …
pump‐probe molecular dynamics, excites selected atoms or residues with a set of oscillating …
[HTML][HTML] Neurogranin alters the structure and calcium binding properties of calmodulin
L Hoffman, A Chandrasekar, X Wang, JA Putkey… - Journal of Biological …, 2014 - ASBMB
Neurogranin (Ng) is a member of the IQ motif class of calmodulin (CaM)-binding proteins,
and interactions with CaM are its only known biological function. In this report we …
and interactions with CaM are its only known biological function. In this report we …
[HTML][HTML] Lobe-dependent regulation of ryanodine receptor type 1 by calmodulin
LW Xiong, RA Newman, GG Rodney, O Thomas… - Journal of Biological …, 2002 - ASBMB
Calmodulin activates the skeletal muscle Ca 2+ release channel RYR1 at nmCa 2+
concentrations and inhibits the channel at μm Ca 2+ concentrations. Using a deletion mutant …
concentrations and inhibits the channel at μm Ca 2+ concentrations. Using a deletion mutant …
Probing Ca2+-Induced Conformational Changes in Porcine Calmodulin by H/D Exchange and ESI-MS: Effect of Cations and Ionic Strength
MM Zhu, DL Rempel, J Zhao, DE Giblin, ML Gross - Biochemistry, 2003 - ACS Publications
We applied a new method,“protein− ligand interaction using mass spectrometry, titration,
and H/D exchange”(PLIMSTEX)[Zhu, MM (2003) J. Am. Chem. Soc. 125, 5252− 5253], to …
and H/D exchange”(PLIMSTEX)[Zhu, MM (2003) J. Am. Chem. Soc. 125, 5252− 5253], to …
[HTML][HTML] A molecular dynamics study of Ca2+-calmodulin: evidence of interdomain coupling and structural collapse on the nanosecond timescale
CM Shepherd, HJ Vogel - Biophysical journal, 2004 - cell.com
A 20-ns molecular dynamics simulation of Ca 2+-calmodulin (CaM) in explicit solvent is
described. Within 5ns, the extended crystal structure adopts a compact shape similar in …
described. Within 5ns, the extended crystal structure adopts a compact shape similar in …
Role of the N- and C-Lobes of Calmodulin in the Activation of Ca2+/Calmodulin-Dependent Protein Kinase II
A Forest, MT Swulius, JKY Tse, JM Bradshaw… - Biochemistry, 2008 - ACS Publications
Understanding the principles of calmodulin (CaM) activation of target enzymes will help
delineate how this seemingly simple molecule can play such a complex role in transducing …
delineate how this seemingly simple molecule can play such a complex role in transducing …
Thermodynamics of Calcium binding to the Calmodulin N-terminal domain to evaluate site-specific affinity constants and cooperativity
MR Beccia, S Sauge-Merle, D Lemaire… - JBIC Journal of …, 2015 - Springer
Calmodulin (CaM) is an essential Ca (II)-dependent regulator of cell physiology. To
understand its interaction with Ca (II) at a molecular level, it is essential to examine Ca (II) …
understand its interaction with Ca (II) at a molecular level, it is essential to examine Ca (II) …