Activation and inhibition of sodium-hydrogen exchanger is a mechanism that links the pathophysiology and treatment of diabetes mellitus with that of heart failure

M Packer - Circulation, 2017 - Am Heart Assoc
The mechanisms underlying the progression of diabetes mellitus and heart failure are
closely intertwined, such that worsening of one condition is frequently accompanied by …

Multifarious molecular signaling cascades of cardiac hypertrophy: can the muddy waters be cleared?

P Balakumar, G Jagadeesh - Pharmacological research, 2010 - Elsevier
The mammalian heart during its development and in response to physiological or
pathological stimuli undergoes hypertrophic enlargement, a consequence of an increase in …

Attenuating vascular stenosis-induced astrogliosis preserves white matter integrity and cognitive function

Q Liu, MIH Bhuiyan, R Liu, S Song, G Begum… - Journal of …, 2021 - Springer
Background Chronic cerebral hypoperfusion (CCH) causes white matter damage and
cognitive impairment, in which astrogliosis is the major pathology. However, underlying …

Role of α-crystallin B as a regulatory switch in modulating cardiomyocyte apoptosis by mitochondria or endoplasmic reticulum during cardiac hypertrophy and …

A Mitra, T Basak, K Datta, S Naskar, S Sengupta… - Cell death & …, 2013 - nature.com
Cardiac hypertrophy and myocardial infarction (MI) are two major causes of heart failure with
different etiologies. However, the molecular mechanisms associated with these two …

Regulation of the cardiac Na+/H+ exchanger in health and disease

S Wakabayashi, T Hisamitsu, TY Nakamura - Journal of molecular and …, 2013 - Elsevier
The Na+ gradient produced across the cardiac sarcolemma by the ATP-dependent Na+-
pump is a constant source of energy for Na+-dependent transporters. The plasma …

Hypoxia-induced invadopodia formation involves activation of NHE-1 by the p90 ribosomal S6 kinase (p90RSK)

F Lucien, K Brochu-Gaudreau, D Arsenault, K Harper… - PloS one, 2011 - journals.plos.org
The hypoxic and acidic microenvironments in tumors are strongly associated with malignant
progression and metastasis, and have thus become a central issue in tumor physiology and …

The HVCN1 voltage‐gated proton channel contributes to pH regulation in canine ventricular myocytes

J Ma, X Gao, Y Li, TE DeCoursey… - The Journal of …, 2022 - Wiley Online Library
Regulation of intracellular pH (pHi) in cardiomyocytes is crucial for cardiac function;
however, currently known mechanisms for direct or indirect extrusion of acid from …

Cardioprotective role of IGF‐1 in the hypertrophied myocardium of the spontaneously hypertensive rats: a key effect on NHE‐1 activity

AM Yeves, JI Burgos, AJ Medina… - Acta …, 2018 - Wiley Online Library
Abstract Aim Myocardial Na+/H+ exchanger‐1 (NHE‐1) hyperactivity and oxidative stress
are interrelated phenomena playing pivotal roles in the development of pathological cardiac …

H+-activated Na+ influx in the ventricular myocyte couples Ca2+-signalling to intracellular pH

CD Garciarena, JB Youm, P Swietach… - Journal of molecular and …, 2013 - Elsevier
Acid extrusion on Na+-coupled pH-regulatory proteins (pH-transporters), Na+/H+ exchange
(NHE1) and Na+-HCO 3− co-transport (NBC), drives Na+ influx into the ventricular myocyte …

Role of autocrine/paracrine mechanisms in response to myocardial strain

HE Cingolani, IL Ennis, EA Aiello, NG Pérez - Pflügers Archiv-European …, 2011 - Springer
Myocardial strain triggers an autocrine/paracrine mechanism known to participate in
myocardial hypertrophy development. After the onset of stretch, there is a rapid …