Monoclonal antibody (mAb) therapy has successfully been introduced as treatment of
several lymphomas and leukemias. However, solid tumors reduce the efficacy of mAb …

Abstract Interleukin-12 (IL-12) is a type I cytokine involved in both innate and adaptive
immunity that stimulates T and natural killer cell activity and induces interferon gamma …

Pancreatic cancer is a significant cause of cancer-related deaths in the United States with an
abysmal five-year overall survival rate that is under 9%. Reasons for this mortality include …

Sphingolipids, crucial components of cellular membranes, play a vital role in maintaining
cellular structure and signaling integrity. Disruptions in sphingolipid metabolism are …

Background Radiation therapy (RT) has been demonstrated to generate an in situ
vaccination (ISV) effect in murine models and in patients with cancer; however, this has not …

Abstract CD19 CAR-T (chimeric antigen receptor-T) cell immunotherapy achieves a
remission rate of approximately 70% in recurrent and refractory lymphoma treatment …

Background Surgical resection remains an important component of multimodality treatment
for most solid tumors. Neoadjuvant immunotherapy has several potential advantages …

Sera of immune mice that were previously cured of their melanoma through a combined
radiation and immunocytokine immunotherapy regimen consisting of 12 Gy of external beam …

OX40 is a costimulatory receptor that is expressed primarily on activated CD4+, CD8+, and
regulatory T cells. The ligation of OX40 to its sole ligand OX40L potentiates T cell expansion …

Hoefges et al. utilized a whole-proteome peptide array approach to show that C57BL/6 mice
develop a large repertoire of antibodies against linear peptide sequences of their melanoma …