Importance Uncontrolled and indiscriminate prescribing of opioids has led to an opioid crisis
that started in North America and spread throughout high-income countries. The aim of this …

Surgical care episodes place opioid-naïve patients at risk for transitioning to new persistent
postoperative opioid use. With one of the central principles being the application of …

This international multidisciplinary consensus statement was developed to provide balanced
guidance on the safe peri‐operative use of opioids in adults. An international panel of …

Abstract Purpose Millions of Americans who undergo surgical procedures receive opioid
prescriptions as they return home. While some derive great benefit from these medicines …

Objective: The aim of this study was to evaluate differences in risk of long-term opioid
therapy after surgery among an opioid-naive population using varying cutoffs based on days …

BACKGROUND: Opioid use after surgery is associated with increased health care utilization
and costs. Although some studies show that surgical patients may later become persistent …

BACKGROUND: The treatment of postsurgical pain with prescription opioids has been
associated with persistent opioid use and increased health care utilization and costs …

Purpose: Efforts have begun to implement nonopioid protocols for outpatient urologic
surgery. In this study, we report a retrospective review of the feasibility of implementing a …

Objective To compare the efficacy of pain control and opioid consumption between patients
who receive opioid as primary analgesic therapy and those who receive ibuprofen. Study …

This paper is the forty-second consecutive installment of the annual anthological review of
research concerning the endogenous opioid system, summarizing articles published during …