Background We aimed to map and describe the current state of Mendelian randomization
(MR) literature on cancer risk and to identify associations supported by robust evidence …

We undertook a systematic review and appraised the evidence for an effect of circulating sex
steroid hormones and sex hormone–binding globulin (SHBG) on breast cancer risk in pre …

Background Breast cancer (BC) has the highest cancer incidence and mortality in women
worldwide. Observational epidemiological studies suggest a positive association between …

Background Only a few of the 34 biochemical biomarkers measured in the UK Biobank
(UKB) have been associated with breast cancer, with many associations suffering from …

Many risk factors have been identified for breast cancer. The potential causality for some of
them remains uncertain, and few studies have comprehensively investigated these …

Background Some endogenous hormones have been associated with breast cancer risk,
but the nature of these relationships is not fully understood. Methods UK Biobank was used …

There is still some controversy about the relationship between lipids and venous thrombosis
(VTE). A bidirectional Mendelian randomization (MR) study was conducted to clarify the …

The proportion of patients diagnosed with cancer has been shown to rise with the increasing
aging global population. Advanced age is a major risk factor for morbidity and mortality in …

Simple Summary Obesity increases the risk of postmenopausal, hormone receptor-positive
breast cancer and has been linked to a higher risk of recurrence and mortality. During …

Background Kidney function declines faster in men. Testosterone levels may mediate the
sex disparity. Correspondingly, levels of sex hormone binding globulin (SHBG), which …