Microbial biofilms are communities of aggregated microbial cells embedded in a self-
produced matrix of extracellular polymeric substances (EPS). Biofilms are recalcitrant to …

Chronic non-healing wounds have become a major worldwide healthcare burden. The
impact of biofilms on chronic wound infection is well established. Despite increasing …

Acute infections caused by pathogenic bacteria have been studied extensively for well over
100 years. These infections killed millions of people in previous centuries, but they have …

Background. Increasing antibiotic resistance warrants therapeutic alternatives. Here we
investigated the efficacy of bacteriophage-therapy (phage) alone or combined with …

Bacteria can grow and proliferate either as single, independent cells or organized in
aggregates commonly referred to as biofilms. When bacteria succeed in forming a biofilm …

Type IV pili (T4P) are one of the most common forms of bacterial and archaeal surface
structures, involved in adherence, motility, competence for DNA uptake, and pathogenesis …

▪ Abstract Biofilms can be defined as communities of microorganisms attached to a surface. It
is clear that microorganisms undergo profound changes during their transition from …

In many human infections, hosts and pathogens coexist for years or decades. Important
examples include HIV, herpes viruses, tuberculosis, leprosy, and malaria. With the exception …

▪ Abstract Twitching motility is a flagella-independent form of bacterial translocation over
moist surfaces. It occurs by the extension, tethering, and then retraction of polar type IV pili …

We have developed technologies for creating saturating libraries of sequence-defined
transposon insertion mutants in which each strain is maintained. Phenotypic analysis of …