The intricacy of diseases, shaped by intrinsic processes like immune system exhaustion and
hyperactivation, highlights the potential of immune renormalization as a promising strategy …

As a nontraditional T-cell subgroup, γδT cells have gained popularity in the field of
immunotherapy in recent years. They have extraordinary antitumor potential and prospects …

INTRODUCTION T cells represent a key component of the immune system that can
recognize foreign molecules (antigens) via cognate cell surface receptors termed T cell …

With the promise of T cell-based therapy for cancer finally becoming reality, this Review
focuses on the less-studied γδ T cell lineage and its diverse responses to tumours. γδ T cells …

Summary Vγ9Vδ2 T cells respond in a TCR-dependent fashion to both microbial and host-
derived pyrophosphate compounds (phosphoantigens, or P-Ag). Butyrophilin-3A1 …

Abstract γδ T cells are a unique and conserved population of lymphocytes that have been
the subject of a recent explosion of interest owing to their essential contributions to many …

γδ T cells, αβ T cells, and B cells are present together in all but the most primitive
vertebrates, suggesting that each population contributes to host immune competence …

T lymphocytes comprise cells expressing either an αβ or a γδ TCR. The riddle how αβ TCRs
are triggered by specific peptides presented in the context of MHC was elucidated some …

In humans, Vγ9Vδ2 T cells detect tumor cells and microbial infections, including
Mycobacterium tuberculosis, through recognition of small pyrophosphate containing organic …

Human peripheral Vγ9Vδ2 T cells are activated by phosphorylated metabolites
(phosphoagonists [PAg]) of the mammalian mevalonate or the microbial desoxyxylulose …