Cholesterol is a ubiquitous sterol with many biological functions, which are crucial for proper
cellular signaling and physiology. Indeed, cholesterol is essential in maintaining membrane …

During the past two decades invasive fungal infections have emerged as major causes of
morbidity and mortality in immunocompromised patients. Several factors have contributed to …

Production of farnesol by Candida albicans is the first quorum-sensing system discovered in
a eukaryote (29). In C. albicans, accumulated farnesol affects both dimorphism (29, 50) and …

Squalene synthase catalyzes the biosynthesis of squalene, a key cholesterol precursor,
through a reductive dimerization of two farnesyl diphosphate (FPP) molecules. The reaction …

Simple Summary Squalene synthase is a key enzyme that not only participates in the
mevalonate pathway, resulting in cholesterol, but also acts as a potential ferroptosis …

Organic extracts from cultures of endophytic fungi collected in the Guanacaste Conservation
Area of Costa Rica were screened for antibiotic activity. Two endophytes CR200 (Cytospora …

Sterols are constituents of the cellular membranes that are essential for their normal
structure and function. In mammalian cells, cholesterol is the main sterol found in the various …

3.1 Introduction 3.2 Studies on the roles of PKS cluster components—hybrid clusters 3.3 7,
9, 12-Octaketides 3.3. 1 Actinorhodin 3.3. 1.1 Regulation 3.3. 1.2 Malonyl transferase (MT) …

Our previous morphological studies illustrated the association of sterols with Plasmodium
infecting hepatocytes. Because malaria parasites cannot synthesize sterols, they must …

Introduction There has been renewed interest in mushroom medicinal properties. We
studied cholesterol lowering properties of Ganoderma lucidum (Gl), a renowned medicinal …