Non-specific effects of vaccines: current evidence and potential implications

LCJ De Bree, VACM Koeken, LAB Joosten… - Seminars in …, 2018 - Elsevier
Besides protection against specific microorganisms, vaccines can induce heterologous or
non-specific effects (NSE). Epidemiological data suggest that vaccination with live …

Measles, immune suppression and vaccination: direct and indirect nonspecific vaccine benefits

MJ Mina - Journal of Infection, 2017 - Elsevier
The measles virus is among the most transmissible viruses known to infect humans. Prior to
measles vaccination programs, measles infected over 95% of all children and was …

Long-term measles-induced immunomodulation increases overall childhood infectious disease mortality

MJ Mina, CJE Metcalf, RL De Swart, A Osterhaus… - Science, 2015 - science.org
Immunosuppression after measles is known to predispose people to opportunistic infections
for a period of several weeks to months. Using population-level data, we show that measles …

Non-specific effects of standard measles vaccine at 4.5 and 9 months of age on childhood mortality: randomised controlled trial

P Aaby, CL Martins, ML Garly, C Balé, A Andersen… - Bmj, 2010 - bmj.com
Objective To examine in a randomised trial whether a 25% difference in mortality exists
between 4.5 months and 3 years of age for children given two standard doses of Edmonston …

Non-specific beneficial effect of measles immunisation: analysis of mortality studies from developing countries

P Aaby, B Samb, F Simondon, AMC Seck, K Knudsen… - Bmj, 1995 - bmj.com
Objective: To examine whether the reduction in mortality after standard titre measles
immunisation in developing countries can be explained simply by the prevention of acute …

Acute lower respiratory tract infections and respiratory syncytial virus in infants in Guinea-Bissau: a beneficial effect of BCG vaccination for girls: community based …

LG Stensballe, E Nante, IP Jensen, PE Kofoed… - Vaccine, 2005 - Elsevier
Among measles unvaccinated infants in Guinea-Bissau, we tested whether case infants with
acute lower respiratory tract infection (ALRI), especially ALRI caused by respiratory syncytial …

The long-term effects of measles vaccination on earnings and employment

A Atwood - American Economic Journal: Economic Policy, 2022 - aeaweb.org
The measles vaccine was introduced in 1963. Take-up of the vaccine in the United States
occurred quickly and universally, leading to reductions in morbidity and mortality. New …

Testing the hypothesis that diphtheria–tetanus–pertussis vaccine has negative non-specific and sex-differential effects on child survival in high-mortality countries

P Aaby, C Benn, J Nielsen, IM Lisse, A Rodrigues… - BMJ open, 2012 - bmjopen.bmj.com
Background Measles vaccines (MV) have sex-differential effects on mortality not explained
by protection against measles infection. Objective The authors examined whether whole-cell …

Chasing success: health sector aid and mortality

SE Wilson - World Development, 2011 - Elsevier
As many cases studies show, successful public health measures are being implemented in
many places around the globe, and country-level mortality has fallen significantly in recent …

Evasion of host defenses by measles virus: wild-type measles virus infection interferes with induction of alpha/beta interferon production

D Naniche, A Yeh, D Eto, M Manchester… - Journal of …, 2000 - Am Soc Microbiol
Measles is a highly contagious disease currently responsible for over one million childhood
deaths, particularly in the developing world. Since alpha/beta interferons (IFNs) are pivotal …