ANGPTL8 in metabolic homeostasis: more friend than foe?

C Guo, C Wang, X Deng, J He, L Yang… - Open …, 2021 - royalsocietypublishing.org
ANGPTL8 is an important cytokine, which is significantly increased in type 2 diabetes
mellitus (T2DM), obesity and metabolic syndrome. Many studies have shown that ANGPTL8 …

Omics-based biomarkers in the diagnosis of diabetes

WZ Gan, V Ramachandran, CSY Lim… - Journal of Basic and …, 2020 - degruyter.com
Diabetes mellitus (DM) is a group of metabolic diseases related to the dysfunction of insulin,
causing hyperglycaemia and life-threatening complications. Current early screening and …

Higher circulating levels of ANGPTL8 are associated with body mass index, triglycerides, and endothelial dysfunction in patients with coronary artery disease

R Fadaei, H Shateri, JK DiStefano, N Moradi… - Molecular and cellular …, 2020 - Springer
Bac Coronary artery disease (CAD) is the leading cause of death worldwide and most
commonly develops as a result of atherosclerosis. ANGPTL8 is a secreted adipokine that …

Angiopoietin-like protein 8 in early pregnancy improves the prediction of gestational diabetes

Y Huang, X Chen, X Chen, Y Feng, H Guo, S Li, T Dai… - Diabetologia, 2018 - Springer
Aims/hypothesis Screening high-risk individuals for gestational diabetes mellitus (GDM) in
early pregnancy conventionally relies on established maternal risk factors; however, the …

Association of ANGPTL8 (betatrophin) gene variants with components of metabolic syndrome in Arab adults

A Alenad, MM Alenezi, MS Alokail, K Wani… - Scientific Reports, 2020 - nature.com
Abstract Angiopoietin-like protein 8 (ANGPTL8) has a role in lipid metabolism, beta-cell
proliferation and diabetes progression, however, the association between different variants …

Association between circulating microRNAs 486, 146b and 15b and serum betatrophin levels in obese; type 2 diabetic and non-diabetic children

KM Mohany, O Al Rugaie, O Al-Wutayd… - BMC Endocrine …, 2020 - Springer
Background This study tested the association between serum levels of microRNA-486,−
146b and-15b and betatrophin in normal and obese children with/without type 2 diabetes …

Angiopoietin-like protein 8: an attractive biomarker for the evaluation of subjects with insulin resistance and related disorders

S Wang, X Hong, Z Tu, G Yuan - diabetes research and clinical practice, 2017 - Elsevier
Insulin resistance is prevalent worldwide and is associated with many metabolic diseases, in
particular, type 2 diabetes mellitus (T2DM), obesity, nonalcoholic fatty liver disease …

Circulating betatrophin in relation to metabolic, inflammatory parameters, and oxidative stress in patients with type 2 diabetes mellitus

AB Hassan, SF Salih, II Hassan, FS Saadi… - Diabetes & Metabolic …, 2019 - Elsevier
Aims Recently, it was suggested that betatrophin has a role in controlling pancreatic β cell
proliferation and lipid metabolism, however, its role in human subjects has not been …

The ANGPTL8 rs2278426 (C/T) Polymorphism Is Associated with Prediabetes and Type 2 Diabetes in a Han Chinese Population in Hebei Province

G Hou, Y Tang, L Ren, Y Guan, X Hou… - International Journal of …, 2020 - Wiley Online Library
Background. Our aim was to investigate the association between the genetics of the
angiopoietin protein‐like 8 (ANGPTL8) rs2278426 (C/T) polymorphism with prediabetes (pre …

[PDF][PDF] Serum betatrophin concentrations and the risk of incident diabetes: A nested case-control study from chungju metabolic disease cohort

SH Lee, M Rhee, HS Kwon, YM Park… - … & metabolism journal, 2018 - synapse.koreamed.org
Background: Betatrophin is a newly identified hormone derived from the liver and adipose
tissue, which has been suggested to regulate glucose and lipid metabolism. Circulating …