Publisher Summary Combinatorial antibodies will play a significant role in the design of
vaccines and new antiviral agents. Antibodies may also provide a way of determining …

The ability of antibodies to neutralize diverse primary isolates of human immunodeficiency
virus-type 1 in vitro has been questioned, with implications for the likely efficacy of vaccines …

Neutralizing antibody assays are powerful tools for assessing humoral immunity in AIDS
virus infection and vaccine development. Although many different assays have been …

A recently developed tetrazolium-based microculture assay was used to screen extracts of
cultured cyanobacteria (blue-green algae) for inhibition of the cytopathic effects of the …

An aqueous extract of the blue-green filamentous algae Arthrospira platensis (previously
called Spirulina platensis) inhibited HIV-1 replication in human T-cell lines, peripheral blood …

A method is described that allows for the improvement of antibody affinity. This method,
termed complementary-determining region (CDR) walking, does not require structural …

We have established a hybridoma clone, designated 2F5, secreting a neutralizing human
monoclonal antibody (MAb) specific for gp41 of human immunodeficiency virus type 1 (HIV …

To determine the factors governing inactivation and neutralization, physical, chemical, and
biological assays were performed on a molecular clone of human immunodeficiency type 1 …

A panel of 20 recombinant Fab fragments reactive with the surface glycoprotein gp120 of
human type 1 immunodeficiency virus (HIV-1) were examined for their ability to neutralize …

Identification and quantitation of cellular proteins associated with HIV-1 particles are
complicated by the presence of nonvirion-associated cellular proteins that copurify with …