The past few years have provided important insights into the genetic architecture of systemic
autoimmunity through aggregation of findings from genome-wide association studies …

Receptors of the innate immune system recognize conserved microbial features and provide
key signals that initiate immune responses. Multiple transmembrane and cytosolic receptors …

The mechanisms that drive normal B cell differentiation and activation are frequently
subverted by B cell lymphomas for their unlimited growth and survival. B cells are …

Plasmacytoid dendritic cells (pDCs) are a unique subset of dendritic cells specialised in
secreting high levels of type I interferons. pDCs play a crucial role in antiviral immunity and …

Women develop stronger immune responses than men, with positive effects on the
resistance to viral or bacterial infections but magnifying also the susceptibility to autoimmune …

Dysregulated germinal center (GC) responses are implicated in the pathogenesis of human
autoimmune diseases, including systemic lupus erythematosus (SLE). Although both type 1 …

Intrarenal B cells in human renal allografts indicate transplant recipients with a poor
prognosis, but how these cells contribute to rejection is unclear. Here we show using single …

Type I interferons (IFNs) are a family of cytokines involved in the defense against viral
infections that play a key role in the activation of both the innate and adaptive immune …

The contribution of dyslipidemia and inflammation in atherosclerosis is well established.
Along with effective lipid-lowering treatments, the recent success of clinical trials with anti …

The discovery of host‐encoded gene products that sense molecular patterns in infectious
microbes, and the demonstration of their role in triggering innate and adaptive immune …