Neural dedifferentiation in the aging brain

JD Koen, MD Rugg - Trends in cognitive sciences, 2019 - cell.com
Many cognitive abilities decline with age even in the absence of detectable pathology.
Recent evidence indicates that age-related neural dedifferentiation, operationalized in terms …

Inhibitory stabilization and cortical computation

S Sadeh, C Clopath - Nature Reviews Neuroscience, 2021 - nature.com
Neuronal networks with strong recurrent connectivity provide the brain with a powerful
means to perform complex computational tasks. However, high-gain excitatory networks are …

[HTML][HTML] Functional dedifferentiation and altered connectivity in older adults: neural accounts of cognitive aging

JOS Goh - Aging and disease, 2011 - ncbi.nlm.nih.gov
Aging is associated with myriad changes in behavioral performance and brain structure and
function. Given this complex interplay of brain and behavior, two streams of findings are …

The aging motor system as a model for plastic changes of GABA-mediated intracortical inhibition and their behavioral relevance

KF Heise, M Zimerman, J Hoppe, C Gerloff… - Journal of …, 2013 - Soc Neuroscience
Since GABAA-mediated intracortical inhibition has been shown to underlie plastic changes
throughout the lifespan from development to aging, here, the aging motor system was used …

Reduced neural selectivity increases fMRI adaptation with age during face discrimination

JO Goh, A Suzuki, DC Park - Neuroimage, 2010 - Elsevier
Ventral–visual activity in older adults has been characterized by dedifferentiation, or
reduced distinctiveness, of responses to different categories of visual stimuli such as faces …

[HTML][HTML] Differential aging of motion processing mechanisms: Evidence against general perceptual decline

J Billino, F Bremmer, KR Gegenfurtner - Vision research, 2008 - Elsevier
While the percentage of older people in our society is steadily increasing, knowledge about
perceptual changes during healthy aging is still limited. We investigated age effects on …

Decreased proportion of GABA neurons accompanies age-related degradation of neuronal function in cat striate cortex

T Hua, C Kao, Q Sun, X Li, Y Zhou - Brain research bulletin, 2008 - Elsevier
Electrophysiological studies indicate that a decline of GABAergic inhibition in the visual
cortex may underlie age-related degradation of visual function [AG Leventhal, Y. Wang, M …

Occipital GABA levels in older adults and their relationship to visual perceptual suppression

K Pitchaimuthu, Q Wu, O Carter, BN Nguyen, S Ahn… - Scientific Reports, 2017 - nature.com
Several studies have attributed certain visual perceptual alterations in older adults to a likely
decrease in GABA (Gamma Aminobutyric Acid) concentration in visual cortex, an …

[HTML][HTML] The effects of aging on orientation discrimination

LR Betts, AB Sekuler, PJ Bennett - Vision research, 2007 - Elsevier
The current experiments measured orientation discrimination thresholds in younger (mean
age≈ 23 years) and older (mean age≈ 66 years) subjects. In Experiment 1, the contrast …

Modality-specificity of sensory aging in vision and audition: evidence from event-related potentials

R Čeponienė, M Westerfield, M Torki, J Townsend - Brain research, 2008 - Elsevier
Major accounts of aging implicate changes in processing external stimulus information. Little
is known about differential effects of auditory and visual sensory aging, and the mechanisms …