Depression is one of the leading causes of disability, and, if left unmanaged, it can increase
the risk for suicide. The evidence base on the determinants of depression is fragmented …

Depression is a heterogeneous and etiologically complex psychiatric syndrome, not a
unitary disease entity, encompassing a broad spectrum of psychopathology arising from …

Major depressive disorder (MDD) is a common, debilitating, phenotypically heterogeneous
disorder with heritability ranges from 30% to 50%. Compared to other psychiatric disorders …

Genome-wide association studies (GWASs) have identified numerous risk genes for
depression. Nevertheless, genes crucial for understanding the molecular mechanisms of …

Major depressive disorder (MDD) is phenotypically associated with cardiovascular diseases
(CVD). We aim to investigate mechanisms underlying relationships between MDD and CVD …

Major depressive disorder (MDD) is a complex and heterogeneous psychiatric syndrome
with genetic and environmental influences. In addition to neuroanatomical and circuit-level …

In the brain, cell adhesion molecules (CAMs) are critical for neurite outgrowth, axonal
fasciculation, neuronal survival and migration, and synapse formation and maintenance …

Previous genome-wide association studies (GWAS) have identified potential genetic
variants associated with the risk of major depressive disorder (MDD), but the underlying …

Background Identifying novel molecular drivers of disease progression in heart failure (HF)
is a high‐priority goal that may provide new therapeutic targets to improve patient outcomes …

Background Studies have shown an association between depression and circulating
metabolites, but the causal relationship between them has not been elucidated. The …