Insights into recent findings and clinical application of YAP and TAZ in cancer
Decades of research have mapped out the basic mechanics of the Hippo pathway. The
paralogues Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding …
paralogues Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding …
The Hippo signalling pathway and its implications in human health and diseases
M Fu, Y Hu, T Lan, KL Guan, T Luo… - Signal transduction and …, 2022 - nature.com
As an evolutionarily conserved signalling network, the Hippo pathway plays a crucial role in
the regulation of numerous biological processes. Thus, substantial efforts have been made …
the regulation of numerous biological processes. Thus, substantial efforts have been made …
Therapeutic targeting of TEAD transcription factors in cancer
The Hippo signaling pathway inhibits the activity of the oncogenic YAP (Yes-associated
protein)/TAZ (transcriptional co-activator with PDZ-binding motif)–TEAD (TEA/ATTS domain) …
protein)/TAZ (transcriptional co-activator with PDZ-binding motif)–TEAD (TEA/ATTS domain) …
The hippo pathway effectors YAP/TAZ-TEAD oncoproteins as emerging therapeutic targets in the tumor microenvironment
Simple Summary YAP/TAZ are the central effectors of the Hippo pathway and orchestrate
their oncogenic program by binding to TEAD transcriptional factors. Here, we document a …
their oncogenic program by binding to TEAD transcriptional factors. Here, we document a …
The Hippo signaling pathway in development and regeneration
The Hippo signaling pathway is a central growth control mechanism in multicellular
organisms. By integrating diverse mechanical, biochemical, and stress cues, the Hippo …
organisms. By integrating diverse mechanical, biochemical, and stress cues, the Hippo …
New insights into YAP/TAZ-TEAD-mediated gene regulation and biological processes in cancer
Simple Summary The Hippo pathway is crucial for regulating cell growth, organ size, and
tissue regeneration. When this pathway goes awry, it can lead to uncontrolled cell growth …
tissue regeneration. When this pathway goes awry, it can lead to uncontrolled cell growth …
Integrated screens uncover a cell surface tumor suppressor gene KIRREL involved in Hippo pathway
Cell surface proteins play essential roles in various biological processes and are highly
related to cancer development. They also serve as important markers for cell identity and …
related to cancer development. They also serve as important markers for cell identity and …
Transmembrane protein KIRREL1 regulates Hippo signaling via a feedback loop and represents a therapeutic target in YAP/TAZ-active cancers
The Hippo tumor-suppressor pathway is frequently dysregulated in human cancers and
represents a therapeutic target. However, strategies targeting the mammalian Hippo …
represents a therapeutic target. However, strategies targeting the mammalian Hippo …
NIBR-LTSi is a selective LATS kinase inhibitor activating YAP signaling and expanding tissue stem cells in vitro and in vivo
K Namoto, C Baader, V Orsini, A Landshammer… - Cell Stem Cell, 2024 - cell.com
The YAP/Hippo pathway is an organ growth and size regulation rheostat safeguarding
multiple tissue stem cell compartments. LATS kinases phosphorylate and thereby inactivate …
multiple tissue stem cell compartments. LATS kinases phosphorylate and thereby inactivate …
A biomimetic nanoplatform for customized photothermal therapy of HNSCC evaluated on patient-derived xenograft models
Q Wu, L Chen, X Huang, J Lin, J Gao, G Yang… - International Journal of …, 2023 - nature.com
Cancer cell membrane (CCM) derived nanotechnology functionalizes nanoparticles (NPs) to
recognize homologous cells, exhibiting translational potential in accurate tumor therapy …
recognize homologous cells, exhibiting translational potential in accurate tumor therapy …