Immunologic mechanisms in asthma

T Boonpiyathad, ZC Sözener, P Satitsuksanoa… - Seminars in …, 2019 - Elsevier
Asthma is a chronic airway disease, which affects more than 300 million people. The
pathogenesis of asthma exhibits marked heterogeneity with many phenotypes defining …

The chemokine system in innate immunity

CL Sokol, AD Luster - Cold Spring Harbor perspectives …, 2015 - cshperspectives.cshlp.org
Chemokines are chemotactic cytokines that control the migration and positioning of immune
cells in tissues and are critical for the function of the innate immune system. Chemokines …

Chemokines and chemokine receptors: positioning cells for host defense and immunity

JW Griffith, CL Sokol, AD Luster - Annual review of immunology, 2014 - annualreviews.org
Chemokines are chemo tactic cyto kines that control the migratory patterns and positioning
of all immune cells. Although chemokines were initially appreciated as important mediators …

Thymic stromal lymphopoietin: its role and potential as a therapeutic target in asthma

GM Gauvreau, R Sehmi, CS Ambrose… - Expert opinion on …, 2020 - Taylor & Francis
Introduction Thymic stromal lymphopoietin (TSLP), an epithelial cytokine (alarmin), is a
central regulator of the immune response to inhaled environmental insults such as …

Thymic stromal lymphopoietin isoforms, inflammatory disorders, and cancer

G Varricchi, A Pecoraro, G Marone… - Frontiers in …, 2018 - frontiersin.org
Thymic stromal lymphopoietin (TSLP) is a pleiotropic cytokine originally isolated from a
murine thymic stromal cell line. TSLP exerts its biological effects by binding to a high-affinity …

Early local immune defences in the respiratory tract

A Iwasaki, EF Foxman, RD Molony - Nature Reviews Immunology, 2017 - nature.com
The respiratory immune response consists of multiple tiers of cellular responses that are
engaged in a sequential manner in order to control infections. The stepwise engagement of …

Eosinophils: changing perspectives in health and disease

HF Rosenberg, KD Dyer, PS Foster - Nature Reviews Immunology, 2013 - nature.com
Eosinophils have been traditionally perceived as terminally differentiated cytotoxic effector
cells. Recent studies have profoundly altered this simplistic view of eosinophils and their …

Eosinophil knockout humans: uncovering the role of eosinophils through eosinophil-directed biological therapies

EA Jacobsen, DJ Jackson, E Heffler… - Annual review of …, 2021 - annualreviews.org
The enigmatic eosinophil has emerged as an exciting component of the immune system,
involved in a plethora of homeostatic and inflammatory responses. Substantial progress has …

Targeting eosinophils in allergy, inflammation and beyond

PC Fulkerson, ME Rothenberg - Nature reviews Drug discovery, 2013 - nature.com
Eosinophils can regulate local immune and inflammatory responses, and their accumulation
in the blood and tissue is associated with several inflammatory and infectious diseases …

New cytokines in the pathogenesis of atopic dermatitis—new therapeutic targets

J Klonowska, J Gleń, RJ Nowicki… - International journal of …, 2018 - mdpi.com
Atopic dermatitis (AD) is a recurrent, chronic, and inflammatory skin disease, which
processes with severe itchiness. It often coexists with different atopic diseases. The number …