Pathogenesis of COVID‐19 described through the lens of an undersulfated and degraded epithelial and endothelial glycocalyx

HN du Preez, C Aldous, MR Hayden… - The FASEB …, 2022 - Wiley Online Library
The glycocalyx surrounds every eukaryotic cell and is a complex mesh of proteins and
carbohydrates. It consists of proteoglycans with glycosaminoglycan side chains, which are …

[HTML][HTML] Clinical approach to post-acute sequelae after COVID-19 infection and vaccination

N Hulscher, BC Procter, C Wynn, PA McCullough - Cureus, 2023 - ncbi.nlm.nih.gov
The spike protein of SARS-CoV-2 has been found to exhibit pathogenic characteristics and
be a possible cause of post-acute sequelae after SARS-CoV-2 infection or COVID-19 …

N‐Acetylcysteine and Other Sulfur‐Donors as a Preventative and Adjunct Therapy for COVID‐19

HN du Preez, C Aldous, HG Kruger… - Advances in …, 2022 - Wiley Online Library
The airway epithelial glycocalyx plays an important role in preventing severe acute
respiratory syndrome coronavirus 2 entry into the epithelial cells, while the endothelial …

How aging and oxidative stress influence the cytopathic and inflammatory effects of SARS-CoV-2 infection: The role of cellular glutathione and cysteine metabolism

F Galli, G Marcantonini, D Giustarini, MC Albertini… - Antioxidants, 2022 - mdpi.com
SARS-CoV-2 infection can cause a severe respiratory distress syndrome with inflammatory
and thrombotic complications, the severity of which increases with patients' age and …

Strategies for the management of spike protein-related pathology

MTJ Halma, C Plothe, P Marik, TA Lawrie - Microorganisms, 2023 - mdpi.com
In the wake of the COVID-19 crisis, a need has arisen to prevent and treat two related
conditions, COVID-19 vaccine injury and long COVID-19, both of which can trace at least …

[HTML][HTML] The age-dependent decline of the extracellular thiol-disulfide balance and its role in SARS-CoV-2 infection

D Giustarini, A Santucci, D Bartolini, F Galli, R Rossi - Redox Biology, 2021 - Elsevier
Abstract SARS–CoV-2 (COVID-19) infection can cause a severe respiratory distress
syndrome. The risk of severe manifestations and mortality characteristically increase in the …

Use of thiols in the treatment of COVID-19: current evidence

M Cazzola, P Rogliani, SS Salvi, J Ora, MG Matera - Lung, 2021 - Springer
There is a possible role for oxidative stress, a state characterized by an altered balance
between the production of free radicals or reactive oxygen species (ROS) and antioxidant …

[HTML][HTML] Trends of mutation accumulation across global SARS-CoV-2 genomes: Implications for the evolution of the novel coronavirus

C Roy, SM Mandal, SK Mondal, S Mukherjee… - Genomics, 2020 - Elsevier
To understand SARS-CoV-2 microevolution, this study explored the genome-wide
frequency, gene-wise distribution, and molecular nature of all point-mutations detected …

The biogenesis of SARS-CoV-2 spike glycoprotein: multiple targets for host-directed antiviral therapy

S Santopolo, A Riccio, MG Santoro - Biochemical and Biophysical …, 2021 - Elsevier
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of
COVID-19 (coronavirus disease-19), represents a far more serious threat to public health …

Clinical Approach to Post-acute Sequelae After COVID-19 Infection and Vaccination

H Nicolas, BC Procter, W Cade, PA McCullough - Cureus, 2023 - search.proquest.com
The spike protein of SARS-CoV-2 has been found to exhibit pathogenic characteristics and
be a possible cause of post-acute sequelae after SARS-CoV-2 infection or COVID-19 …