Phosphate is an essential macronutrient for fungal proliferation as well as a key mediator of
antagonistic, beneficial, and pathogenic interactions between fungi and other organisms. In …

Cryptococcus neoformans is a common environmental saprophyte and human fungal
pathogen that primarily causes disease in immunocompromised individuals. Similar to many …

Environmental pathogens move from ecological niches to mammalian hosts, requiring
adaptation to dramatically different environments. Microbes that disseminate farther …

Cryptococcus neoformans causes fatal fungal meningoencephalitis. Here, we study the
roles played by fungal kinases and transcription factors (TFs) in blood-brain barrier (BBB) …

There is an urgent need for new antifungal drugs to treat invasive fungal diseases.
Unfortunately, the echinocandin drugs that are fungicidal against other important fungal …

Phosphorus is essential in all cells' structural, metabolic and regulatory functions. For fungal
cells that import inorganic phosphate (Pi) up a steep concentration gradient, surface Pi …

Phosphate and calcium ions are nutrients that play key roles in growth, differentiation and
the production of bioactive secondary metabolites in filamentous fungi. Phosphate …

The fungal pathogen Candida albicans must acquire phosphate to colonize, infect, and
proliferate in the human host. C. albicans has four inorganic phosphate (Pi) transporters …

Phosphate is an essential macronutrient required for cell growth and division. Pho84 is the
major high-affinity cell-surface phosphate importer of Saccharomyces cerevisiae and a …

The ability of pathogenic fungi to acquire essential macro and micronutrients during infection
is a well-established virulence trait. Recent studies in the major human fungal pathogens …