Protein tyrosine phosphatases–from housekeeping enzymes to master regulators of signal transduction

NK Tonks - The FEBS journal, 2013 - Wiley Online Library
There are many misconceptions surrounding the roles of protein phosphatases in the
regulation of signal transduction, perhaps the most damaging of which is the erroneous view …

[41] Use of vanadate as protein-phosphotyrosine phosphatase inhibitor

JA Gordon - Methods in enzymology, 1991 - Elsevier
Publisher Summary This chapter discusses the use of vanadate as protein-phosphotyrosine
phosphatase inhibitor. Vanadium ions have found widespread use as an inhibitor of protein …

Storage of 7±2 short-term memories in oscillatory subcycles

JE Lisman, MAP Idiart - Science, 1995 - science.org
Psychophysical measurements indicate that human subjects can store approximately seven
short-term memories. Physiological studies suggest that short-term memories are stored by …

Mechanism of inhibition of protein-tyrosine phosphatases by vanadate and pervanadate

G Huyer, S Liu, J Kelly, J Moffat, P Payette… - Journal of Biological …, 1997 - ASBMB
Vanadate and pervanadate (the complexes of vanadate with hydrogen peroxide) are two
commonly used general protein-tyrosine phosphatase (PTP) inhibitors. These compounds …

Regulation of NMDA receptors by tyrosine kinases and phosphatases

YT Wang, MW Salter - Nature, 1994 - nature.com
PROTEIN-TYROSINE kinases (PTKs) and protein-tyrosine phosphatases (PTPs) are key
enzymes in signal-transduction pathways for a wide range of cellular processes1, 2. PTKs …

Protein tyrosine phosphatases: a diverse family of intracellular and transmembrane enzymes

EH Fischer, H Charbonneau, NK Tonks - Science, 1991 - science.org
Protein tyrosine phosphatases (PTPs) represent a diverse family of enzymes that exist as
integral membrane and nonreceptor forms. The PTPs, with specific activities in vitro 10 to …

Characterization of the major protein-tyrosine-phosphatases of human placenta.

NK Tonks, CD Diltz, EH Fischer - Journal of Biological Chemistry, 1988 - Elsevier
In the preceding article (Tonks, NK, Diltz, CD, and Fischer, EH (1988) J. Biol. Chem. 263,
6722-6730), the purification of the major protein-tyrosine-phosphatases from human …

Influenza A virus inhibits type I IFN signaling via NF-κB-dependent induction of SOCS-3 expression

EK Pauli, M Schmolke, T Wolff, D Viemann… - PLoS …, 2008 - journals.plos.org
The type I interferon (IFN) system is a first line of defense against viral infections. Viruses
have developed various mechanisms to counteract this response. So far, the interferon …

Dephosphorylation of receptor tyrosine kinases as target of regulation by radiation, oxidants or alkylating agents.

A Knebel, HJ Rahmsdorf, A Ullrich, P Herrlich - The EMBO journal, 1996 - embopress.org
Several non‐physiologic agents such as radiation, oxidants and alkylating agents induce
ligand‐independent activation of numerous receptor tyrosine kinases (RTKs) and of protein …

Synaptic desensitization of NMDA receptors by calcineurin

G Tong, D Shepherd, CE Jahr - Science, 1995 - science.org
Desensitization is a phenomenon that is common to many ligand-gated ion channels but
has been demonstrated only rarely with physiological stimulation. Numerous studies …