Approximately 25 years have passed since the first publication suggesting the Flinders
sensitive line (FSL) rat as an animal model of depression. At least 6 years of research on …

During infancy and early childhood, children develop their ability to regulate their own
emotions and behavior. This development of self-regulatory mechanisms has been …

A certain level of arousal is required for an individual to perform optimally, and the locus
coeruleus norepinephrine (LC-NE) system plays a central role in optimizing arousal. Tonic …

Major depressive disorder (MDD) is one of the leading causes of years lived with disability
and contributor to the burden of disease worldwide. The incidence of MDD has increased …

Individuals with mood disorders or with addiction, impulsivity and some personality
disorders can share in common a dysfunction in how the brain perceives reward, where …

Major depressive disorder (MDD) and diabetes mellitus type II (T2DM) are two of the major
health challenges of our time. It has been shown that MDD and T2DM are highly co-morbid …

The spontaneously hypertensive rat (SHR) has been widely used as a model for studies of
hypertension and attention deficit/hyperactivity disorder. The inbred Wistar-Kyoto (WKY) rat …

The relationship between trait stress-sensitivity, avoidance acquisition and perseveration of
avoidance was examined using male Wistar–Kyoto (WKY) and Sprague–Dawley (SD) rats …

The purpose of the present study was to evaluate for the first time the stress-induced
hypothalamus–pituitary–adrenal (HPA), adrenocorticotropic hormone (ACTH) …

Background: Depression often manifests during adolescence when the development and
networking of social and emotional brain areas is being influenced by hormones. The Wistar …