Pediatric central nervous system (CNS) tumors are the second most common childhood
malignancy and the most common solid tumor in children. The incidence rate of childhood …

Glioblastoma multiforme (GBM) is an aggressive brain tumor with high mortality rates. Due to
its invasiveness, heterogeneity, and incomplete resection, the treatment is very challenging …

Despite significant improvements in pediatric brain tumor therapy and outcome, too many
children still die of disease, and too many survivors experience significant sequelae as a …

The global impact of somatic structural variants (SSVs) on gene expression in pediatric brain
tumors has not been thoroughly characterised. Here, using whole-genome and RNA …

Simple Summary Recent research has enhanced our understanding of the diverse
biological processes that occur in pediatric gliomas; and molecular genetic analysis has …

Abstract Background Nucleotide-specific 5-hydroxymethylcytosine (5hmC) remains
understudied in pediatric central nervous system (CNS) tumors. 5hmC is abundant in the …

Background The study of central nervous system (CNS) tumors is particularly relevant in the
pediatric population because of their relatively high frequency in this demographic and the …

Simple Summary Childhood glioblastoma is an aggressive brain tumor in children that has a
very poor prognosis. Standard therapy includes surgery, irradiation and chemotherapy with …

Methods: The Indian Society of Neuro-Oncology (ISNO) constituted an expert multi-
disciplinary panel with adequate representation from all stakeholders to prepare national …

Central nervous system tumors are the most common solid tumors in pediatrics and
represent the largest cause of childhood cancer-related mortality. Improvements have …