The genetics of bipolar disorder

FJA Gordovez, FJ McMahon - Molecular psychiatry, 2020 - nature.com
Bipolar disorder (BD) is one of the most heritable mental illnesses, but the elucidation of its
genetic basis has proven to be a very challenging endeavor. Genome-Wide Association …

The complement system in schizophrenia: where are we now and what's next?

JJ Woo, JG Pouget, CC Zai, JL Kennedy - Molecular psychiatry, 2020 - nature.com
The complement system is a set of immune proteins involved in first-line defense against
pathogens and removal of waste materials. Recent evidence has implicated the complement …

Genetic background of extreme violent behavior

J Tiihonen, MR Rautiainen, HM Ollila… - Molecular …, 2015 - nature.com
In developed countries, the majority of all violent crime is committed by a small group of
antisocial recidivistic offenders, but no genes have been shown to contribute to recidivistic …

A deep learning approach for predicting antidepressant response in major depression using clinical and genetic biomarkers

E Lin, PH Kuo, YL Liu, YWY Yu, AC Yang… - Frontiers in …, 2018 - frontiersin.org
In the wake of recent advances in scientific research, personalized medicine using deep
learning techniques represents a new paradigm. In this work, our goal was to establish deep …

Genetic contributions to bipolar disorder: current status and future directions

KS O'Connell, BJ Coombes - Psychological Medicine, 2021 - cambridge.org
Bipolar disorder (BD) is a highly heritable mental disorder and is estimated to affect about 50
million people worldwide. Our understanding of the genetic etiology of BD has greatly …

Homocysteine levels in schizophrenia and affective disorders—focus on cognition

AA Moustafa, DH Hewedi, AM Eissa… - Frontiers in behavioral …, 2014 - frontiersin.org
Although homocysteine (Hcy) has been widely implicated in the etiology of various physical
health impairments, especially cardiovascular diseases, overwhelming evidence indicates …

Unravelling the genetic basis of schizophrenia and bipolar disorder with GWAS: A systematic review

DP Prata, B Costa-Neves, G Cosme… - Journal of psychiatric …, 2019 - Elsevier
Objectives To systematically review findings of GWAS in schizophrenia (SZ) and in bipolar
disorder (BD); and to interpret findings, with a focus on identifying independent replications …

Integrated molecular landscape of Parkinson's disease

CJHM Klemann, GJM Martens, M Sharma… - npj Parkinson's …, 2017 - nature.com
Parkinson's disease is caused by a complex interplay of genetic and environmental factors.
Although a number of independent molecular pathways and processes have been …

Cadherin-13, a risk gene for ADHD and comorbid disorders, impacts GABAergic function in hippocampus and cognition

O Rivero, MM Selten, S Sich, S Popp… - Translational …, 2015 - nature.com
Abstract Cadherin-13 (CDH13), a unique glycosylphosphatidylinositol-anchored member of
the cadherin family of cell adhesion molecules, has been identified as a risk gene for …

Gene-environment interactions in the influence of maternal education on adolescent neurodevelopment using ABCD study

R Shi, X Chang, T Banaschewski, GJ Barker… - Science …, 2024 - science.org
Maternal education was strongly correlated with adolescent brain morphology, cognitive
performances, and mental health. However, the molecular basis for the effects of maternal …