Chromatin and epigenetic rearrangements in embryonic stem cell fate transitions

L Sun, X Fu, G Ma, AP Hutchins - Frontiers in cell and developmental …, 2021 - frontiersin.org
A major event in embryonic development is the rearrangement of epigenetic information as
the somatic genome is reprogrammed for a new round of organismal development …

Diversity among POU transcription factors in chromatin recognition and cell fate reprogramming

V Malik, D Zimmer, R Jauch - Cellular and Molecular Life Sciences, 2018 - Springer
Abstract The POU (Pit-Oct-Unc) protein family is an evolutionary ancient group of
transcription factors (TFs) that bind specific DNA sequences to direct gene expression …

Identifying transposable element expression dynamics and heterogeneity during development at the single-cell level with a processing pipeline scTE

J He, IA Babarinde, L Sun, S Xu, R Chen, J Shi… - Nature …, 2021 - nature.com
Transposable elements (TEs) make up a majority of a typical eukaryote's genome, and
contribute to cell heterogeneity in unclear ways. Single-cell sequencing technologies are …

H3K36 methylation maintains cell identity by regulating opposing lineage programmes

MS Hoetker, M Yagi, B Di Stefano, J Langerman… - Nature cell …, 2023 - nature.com
The epigenetic mechanisms that maintain differentiated cell states remain incompletely
understood. Here we employed histone mutants to uncover a crucial role for H3K36 …

Chromatin accessibility dynamics during iPSC reprogramming

D Li, J Liu, X Yang, C Zhou, J Guo, C Wu, Y Qin, L Guo… - Cell stem cell, 2017 - cell.com
Cell-fate decisions remain poorly understood at the chromatin level. Here, we map
chromatin remodeling dynamics during induction of pluripotent stem cells. ATAC-seq …

Functional landscape of PCGF proteins reveals both RING1A/B-dependent-and RING1A/B-independent-specific activities

A Scelfo, D Fernández-Pérez, S Tamburri, M Zanotti… - Molecular cell, 2019 - cell.com
Polycomb repressive complexes 1 and 2 (PRC1 and PRC2) control cell identity by
establishing facultative heterochromatin repressive domains at common sets of target …

In vitro generation of mouse morula-like cells

H Li, L Chang, J Wu, J Huang, W Guan, LE Bates… - Developmental Cell, 2023 - cell.com
Generating cells with the molecular and functional properties of embryo cells and with full
developmental potential is an aim with fundamental biological significance. Here we report …

[HTML][HTML] Transposable elements are regulated by context-specific patterns of chromatin marks in mouse embryonic stem cells

J He, X Fu, M Zhang, F He, W Li, MM Abdul… - Nature …, 2019 - nature.com
The majority of mammalian genomes are devoted to transposable elements (TEs). Whilst
TEs are increasingly recognized for their important biological functions, they are a potential …

[HTML][HTML] A primate-specific endogenous retroviral envelope protein sequesters SFRP2 to regulate human cardiomyocyte development

R Zhang, M Wu, D Xiang, J Zhu, Q Zhang, H Zhong… - Cell Stem Cell, 2024 - cell.com
Endogenous retroviruses (ERVs) occupy a significant part of the human genome, with some
encoding proteins that influence the immune system or regulate cell-cell fusion in early extra …

Metabolic and epigenetic dysfunctions underlie the arrest of in vitro fertilized human embryos in a senescent-like state

Y Yang, L Shi, X Fu, G Ma, Z Yang, Y Li, Y Zhou… - PLoS …, 2022 - journals.plos.org
Around 60% of in vitro fertilized (IVF) human embryos irreversibly arrest before compaction
between the 3-to 8-cell stage, posing a significant clinical problem. The mechanisms behind …