c-Jun N-terminal kinase (JNK) signaling as a therapeutic target for Alzheimer's disease

R Yarza, S Vela, M Solas, MJ Ramirez - Frontiers in pharmacology, 2016 - frontiersin.org
c-Jun N-terminal kinases (JNKs) are a family of protein kinases that play a central role in
stress signaling pathways implicated in gene expression, neuronal plasticity, regeneration …

Targeting the core of neurodegeneration: FoxO, mTOR, and SIRT1

K Maiese - Neural regeneration research, 2021 - journals.lww.com
The global increase in lifespan noted not only in developed nations, but also in large
developing countries parallels an observed increase in a significant number of non …

FoxO3a is activated and executes neuron death via Bim in response to β-amyloid

P Sanphui, SC Biswas - Cell death & disease, 2013 - nature.com
The molecules that mediate death of selective neurons in Alzheimer's disease (AD) are
mostly unknown. The Forkhead transcription factor FoxO3a has emerged as an important …

Targeting protein kinases for the treatment of Alzheimer's disease: recent progress and future perspectives

Z Li, B Yin, S Zhang, Z Lan, L Zhang - European Journal of Medicinal …, 2023 - Elsevier
Alzheimer's disease (AD) is a serious neurodegenerative disease characterized by memory
impairment, mental retardation, impaired motor balance, loss of self-care and even death …

FoxO proteins in the nervous system

K Maiese - Analytical cellular pathology, 2015 - Wiley Online Library
Acute as well as chronic disorders of the nervous system lead to significant morbidity and
mortality for millions of individuals globally. Given the ability to govern stem cell proliferation …

Cognitive impairment in multiple sclerosis

K Maiese - Bioengineering, 2023 - mdpi.com
Almost three million individuals suffer from multiple sclerosis (MS) throughout the world, a
demyelinating disease in the nervous system with increased prevalence over the last five …

Patronin-mediated minus end growth is required for dendritic microtubule polarity

C Feng, P Thyagarajan, M Shorey, DY Seebold… - Journal of Cell …, 2019 - rupress.org
Microtubule minus ends are thought to be stable in cells. Surprisingly, in Drosophila and
zebrafish neurons, we observed persistent minus end growth, with runs lasting over 10 min …

Inhibition of c‐J un N‐terminal kinase activation reverses A lzheimer disease phenotypes in APP swe/PS 1dE 9 mice

Q Zhou, M Wang, Y Du, W Zhang, M Bai… - Annals of …, 2015 - Wiley Online Library
Objective Growing evidence indicates that the activation of c‐Jun N‐terminal kinase (JNK) is
implicated in the multiple major pathological features of Alzheimer disease (AD). However …

Gut microbiota influences Alzheimer's disease pathogenesis by regulating acetate in Drosophila model

Y Kong, B Jiang, X Luo - Future microbiology, 2018 - Taylor & Francis
Aim: The aim of present study is to investigate the relationship between gut microbiota and
Alzheimer's disease (AD) using Drosophila model. Materials & methods: The microbiota was …

[HTML][HTML] Innovative therapeutic strategies for cardiovascular disease

K Maiese - EXCLI journal, 2023 - ncbi.nlm.nih.gov
As a significant non-communicable disease, cardiovascular disease is the leading cause of
death for both men and women, comprises almost twenty percent of deaths in most racial …