Genetic variation in apolipoprotein E (APOE) influences Alzheimer's disease (AD) risk.
APOE ε4 alleles are the strongest genetic risk factor for late onset sporadic AD. The AD risk …

The purpose of our study is to determine the protective effects of mitophagy enhancers
against mutant APP and amyloid beta (Aβ)-induced mitochondrial and synaptic toxicities in …

The purpose of our study is to determine the protective effects of mitophagy enhancers
against phosphorylated tau (P-tau)-induced mitochondrial and synaptic toxicities in …

Advancing age is a major risk factor for Alzheimer's disease (AD). This raises the question of
whether AD biology mechanistically diverges from aging biology or alternatively represents …

Di-(2-ethylhexyl) phthalate (DEHP) is widely used as a plasticizer in plastic products,
consumer products, and packaging materials. It is of great health concern in both animals …

Introduction Mitochondrial dysfunction is observed in Alzheimer's disease (AD). However,
the relationship between functional mitochondrial deficits and AD pathologies is not well …

Background: Mitochondria can trigger Alzheimer's disease (AD)-associated molecular
phenomena, but how mitochondria impact apolipoprotein E (APOE; apoE) is not well known …

Background Apolipoprotein E ε4 (APOE ε4) was shown to be a risk factor for mild cognitive
impairment (MCI) and Alzheimer's disease (AD) dementia. When coupled with sleep …

Obesity is a complex medical condition that affects multiple organs in the body. However, the
underlying mechanisms of obesity, as well as its treatment, are largely unexplored. The …

Abstract Abnormalities in the Tri-Carboxylic-Acid (TCA) cycle have been documented in
dementia. Through network analysis, TCA cycle metabolites could indirectly reflect known …