Hepatocytes form a crucially important cell layer that separates sinusoidal blood from the
canalicular bile. They have a uniquely organized polarity with a basal membrane facing liver …

Formin proteins were recognized as effectors of Rho GTPases some 15 years ago. They
contribute to different cellular actin cytoskeleton structures by their ability to polymerize …

Immune evasion is a pivotal event in tumor progression. To eliminate human cancer cells,
current immune checkpoint therapy is set to boost CD8+ T cell–mediated cytotoxicity …

Hepatocytes, like other epithelia, are situated at the interface between the organism's
exterior and the underlying internal milieu and organize the vectorial exchange of …

Formins are conserved actin polymerization machines that have instrumental roles in
controlling rearrangements of the actin cytoskeleton and have recently been shown to …

Background Charcot–Marie–Tooth neuropathy has been reported to be associated with
renal diseases, mostly focal segmental glomerulosclerosis (FSGS). However, the common …

In cells the de novo nucleation of actin filaments from monomers requires actin-nucleating
proteins. These fall into three main families–the Arp2/3 complex and its nucleation …

Many studies reveal a fundamental role for extracellular matrix-mediated signaling through
integrins and Rho GTPases as well as matrix metalloproteinases (MMPs) in the molecular …

Cdc42–a member of the small Rho GTPase family–regulates cell polarity across organisms
from yeast to humans. It is an essential regulator of polarized morphogenesis in epithelial …

Cells constantly sense and respond to mechanical signals by reorganizing their actin
cytoskeleton. Although a number of studies have explored the effects of mechanical stimuli …