May the force be with you (or not): The immune system under microgravity

M ElGindi, J Sapudom, IH Ibrahim, M Al-Sayegh… - Cells, 2021 - mdpi.com
All terrestrial organisms have evolved and adapted to thrive under Earth's gravitational force.
Due to the increase of crewed space flights in recent years, it is vital to understand how the …

Physical phenotype of blood cells is altered in COVID-19

M Kubánková, B Hohberger, J Hoffmanns, J Fürst… - Biophysical journal, 2021 - cell.com
Clinical syndrome coronavirus disease 2019 (COVID-19) induced by severe acute
respiratory syndrome coronavirus 2 is characterized by rapid spreading and high mortality …

A comparison of microfluidic methods for high-throughput cell deformability measurements

M Urbanska, HE Muñoz, J Shaw Bagnall, O Otto… - Nature …, 2020 - nature.com
The mechanical phenotype of a cell is an inherent biophysical marker of its state and
function, with many applications in basic and applied biological research. Microfluidics …

Mechanosensation and mechanotransduction in natural killer cells

G Santoni, C Amantini, M Santoni, F Maggi… - Frontiers in …, 2021 - frontiersin.org
Natural killer (NK) cells are a main subset of innate lymphocytes that contribute to host
immune protection against viruses and tumors by mediating target cell killing and secreting …

Natural killer cell immune synapse formation and cytotoxicity are controlled by tension of the target interface

D Friedman, P Simmonds, A Hale, L Bere… - Journal of cell …, 2021 - journals.biologists.com
Natural killer (NK) cells can kill infected or transformed cells via a lytic immune synapse.
Diseased cells may exhibit altered mechanical properties but how this impacts NK cell …

Principles and applications of single particle tracking in cell research

Z Wang, X Wang, Y Zhang, W Xu, X Han - Small, 2021 - Wiley Online Library
It is a tough challenge for many decades to decipher the complex relationships between cell
behaviors and cellular physical properties. Single particle tracking (SPT) with high spatial …

The Effects of Combined Exposure to Simulated Microgravity, Ionizing Radiation, and Cortisol on the In Vitro Wound Healing Process

WE Radstake, K Gautam, S Miranda, R Vermeesen… - Cells, 2023 - mdpi.com
Human spaceflight is associated with several health-related issues as a result of long-term
exposure to microgravity, ionizing radiation, and higher levels of psychological stress …

RSV attenuates epithelial cell restitution by inhibiting actin cytoskeleton-dependent cell migration

DT Linfield, N Gao, A Raduka… - … of Physiology-Lung …, 2021 - journals.physiology.org
The airway epithelium's ability to repair itself after injury, known as epithelial restitution, is an
essential mechanism enabling the respiratory tract's normal functions. Respiratory syncytial …

Rapid single-cell physical phenotyping of mechanically dissociated tissue biopsies

D Soteriou, M Kubánková, C Schweitzer… - Nature Biomedical …, 2023 - nature.com
During surgery, rapid and accurate histopathological diagnosis is essential for clinical
decision making. Yet the prevalent method of intra-operative consultation pathology is …

Artificial biosystem for modulation of interactions between antigen‐presenting cells and T cells

A Alatoom, J Sapudom, P Soni… - Advanced …, 2020 - Wiley Online Library
T cell activation is triggered by signal molecules on the surface of antigen‐presenting cells
(APC) and subsequent exertion of cellular forces. Deciphering the biomechanical and …