The endoplasmic reticulum (ER) is an important organelle involved in protein quality control
and cellular homeostasis. The accumulation of unfolded proteins leads to an ER stress …

Astrocytes, oligodendrocytes, and microglia are abundant cell types found in the central
nervous system and have been shown to play crucial roles in regulating both normal and …

A single paragraph of about 200 words maximum. Neurodegenerative diseases (ND), such
as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis, pose a …

Parkinson's disease (PD) is a common neurodegenerative disorder characterized by
selective loss of dopamine neurons in the substantia nigra pars compacta of the midbrain …

Proteostasis (protein homeostasis) refers to the general biological process that maintains
the proper balance between the synthesis of proteins, their folding, trafficking, and …

Objective The mechanistic target of rapamycin (mTOR) kinase is one of the master
coordinators of cellular stress responses, regulating metabolism, autophagy, and apoptosis …

The endoplasmic reticulum (ER) is a complex multifunctional organelle that maintains cell
homeostasis. Intrinsic and extrinsic factors alter ER functions, including the rate of protein …

In the global world diabetes and mitochondrial disease is expected to cost the developing
world in the next 30 years US $400 million. In diabetes an absent peripheral sink amyloid …

Disrupted cellular trafficking and transport processes are hallmarks of many
neurodegenerative disorders (NDs). Recently, efforts have been made toward developing …

Response to cellular stress represents a highly conserved pathway in evolution. Cells
respond to stress with modified synthesis of new proteins by the formation of stress granules …