Respiratory fungal infection is a severe clinical problem, especially in patients with
compromised immune functions. Aspergillus, Cryptococcus, Pneumocystis, and endemic …

Autophagy adjusts cellular biomass and function in response to diverse stimuli, including
infection. Autophagy plays specific roles in shaping immune system development, fueling …

The Class III phosphoinositide 3-kinase Vps34 (vacuolar protein sorting 34) plays important
roles in endocytic trafficking, macroautophagy, phagocytosis, cytokinesis and nutrient …

Cryptococcus neoformans is generally considered to be an opportunistic fungal pathogen
because of its tendency to infect immunocompromised individuals, particularly those …

Cerebral ischemia is a severe outcome that could cause cognitive and motor dysfunction,
neurodegenerative diseases and even acute death. Although the existence of autophagy in …

Autophagy is emerging as a central component of antimicrobial host defense against
diverse viral, bacterial, and parasitic infections. In addition to pathogen degradation …

The opportunistic human fungal pathogen Candida glabrata is closely related to
Saccharomyces cerevisiae, yet it has evolved to survive within mammalian hosts. Which …

Cryptococcus is a unique environmental fungus. Among the more than three dozen species
of Cryptococcus, only C. neoformans and C. gattii commonly cause disease. Although many …

Pathogenic yeasts, either from the environment or the normal flora, have to face phagocytic
cells that constitute the first line of defence during infection. In order to evade or counteract …

Efficient communication with the environment is critical for all living organisms. Fungi utilize
complex signalling systems to sense their environments and control proliferation …