The success of genome-wide association studies (GWASs) has led to increasing interest in
making predictions of complex trait phenotypes, including disease, from genotype data …

A new technology called genomic selection is revolutionizing dairy cattle breeding. Genomic
selection refers to selection decisions based on genomic breeding values (GEBV). The …

ASReml-R is a statistical package that fits linear mixed models using Residual Maximum
Likelihood (REML) in the R environment. This package uses the same computational kernel …

Background The symbiotic rumen microbiota is essential for the digestion of plant fibers and
contributes to the variation of production and health traits in ruminants. However, to date, the …

Stature is affected by many polymorphisms of small effect in humans. In contrast, variation in
dogs, even within breeds, has been suggested to be largely due to variants in a small …

We created waxy corn hybrids by CRISPR–Cas9 editing of a waxy allele in 12 elite inbred
maize lines, a process that was more than a year faster than conventional trait introgression …

Genomic selection can be applied prior to phenotyping, enabling shorter breeding cycles
and greater rates of genetic gain relative to phenotypic selection. Traits measured using …

For most human complex diseases and traits, SNPs identified by genome-wide association
studies (GWAS) explain only a small fraction of the heritability. Here we report a user-friendly …

Generalized linear mixed models provide a flexible framework for modeling a range of data,
although with non-Gaussian response variables the likelihood cannot be obtained in closed …

Meta-analysis has changed the way researchers conduct literature reviews not only in
medical and social sciences but also in biological sciences. Meta-analysis in biological …