Elastic fibers are essential constituents of the extracellular matrix of higher vertebrates and
endow several tissues and organs including lungs, skin and blood vessels with elasticity …

The transforming growth factor β (TGF-β) and bone morphogenetic protein (BMP) signaling
pathways play a pivotal role in bone development and skeletal health. More than 30 different …

Lung-function impairment underlies chronic obstructive pulmonary disease (COPD) and
predicts mortality. In the largest multi-ancestry genome-wide association meta-analysis of …

The a disintegrin-like and metalloproteinase with thrombospondin motif (ADAMTS) family
comprises 19 proteases that regulate the structure and function of extracellular proteins in …

Fibrillin is a large evolutionarily ancient extracellular glycoprotein that assembles to form
beaded microfibrils which are essential components of most extracellular matrices. Fibrillin …

A disintegrin and metalloprotease with thrombospondin type I motifs (ADAMTS) proteases
are secreted metalloproteinases that play key roles in the formation, homeostasis and …

Background A disintegrin and metalloproteinase with thrombospondin motifs 10
(ADAMTS10) plays a role in extracellular matrix and correlates with Weill–Marchesani …

Acromelic dysplasias are a group of rare musculoskeletal disorders that collectively present
with short stature, pseudomuscular build, stiff joints, and tight skin. Acromelic dysplasias are …

Abstract The Zonule of Zinn, or ciliary zonule, is the elaborate system of extracellular fibers
that centers the lens in the eye. In humans, the fibers transmit forces that flatten the lens …

Weill-Marchesani syndrome (WMS) is a rare genetic disorder that affects the
musculoskeletal system, the eye, and the cardiovascular system. Individuals with WMS …