Implant-associated infection (IAI) is increasingly emerging as a serious threat with the
massive application of biomaterials. Bacteria attached to the surface of implants are often …

The increasing incidence and rapid spread of bacterial resistance to conventional antibiotics
are a serious global threat to public health, highlighting the need to develop new …

Aloe emodin-conjugated sulfonyl hydrazones were designed and synthesized as novel type
of antibacterial modulators. Aloe emodin benzenesulfonyl hydrazone 5a (AEBH-5a) was …

Titanium dioxide (TiO 2) is a frequently used biomaterial, particularly in orthopedic and
dental implants, and it is considered an inert and benign compound. This has resulted in …

Numerous epithelial cells and sometimes leukocytes release AMPs as their first line of
defense. AMPs encompass cationic histatins, defensins, and cathelicidin to encounter oral …

Infection is one of the major issues associated with the failure of orthopedic devices, mainly
due to implant bacterial colonization, biofilm formation, and associated antibiotic resistance …

Background Porous metal materials have been widely studied for applications in orthopedic
field, owing to their excellent features and properties in bone healing. Porous metal …

Due to the well-known phenomenon of antibiotic resistance, there is a constant need for
antibiotics with novel mechanisms and different targets respect to those currently in use. In …

Titanium and its alloys are the preferred materials for medical implants. However, easy
infection is a fatal shortcoming of Ti implants. Fortunately, the ongoing development of …

Titanium (Ti) and titanium alloy have been widely used in orthopedics. However, the
successful application of titanium implants is mainly limited due to implant-associated …