Molecular basis of cardioprotection: signal transduction in ischemic pre-, post-, and remote conditioning

G Heusch - Circulation research, 2015 - Am Heart Assoc
Reperfusion is mandatory to salvage ischemic myocardium from infarction, but reperfusion
per se contributes to injury and ultimate infarct size. Therefore, cardioprotection beyond that …

Remote ischemic conditioning

G Heusch, HE Bøtker, K Przyklenk, A Redington… - Journal of the American …, 2015 - jacc.org
In remote ischemic conditioning (RIC), brief, reversible episodes of ischemia with
reperfusion in one vascular bed, tissue, or organ confer a global protective phenotype and …

Pathophysiology of myocardial reperfusion injury: preconditioning, postconditioning, and translational aspects of protective measures

S Sanada, I Komuro, M Kitakaze - American Journal of …, 2011 - journals.physiology.org
Heart diseases due to myocardial ischemia, such as myocardial infarction or ischemic heart
failure, are major causes of death in developed countries, and their number is unfortunately …

Preconditioning the myocardium: from cellular physiology to clinical cardiology

DM Yellon, JM Downey - Physiological reviews, 2003 - journals.physiology.org
Yellon, Derek M., and James M. Downey. Preconditioning the Myocardium: From Cellular
Physiology to Clinical Cardiology. Physiol Rev 83: 1113-1151, 2003; 10.1152/physrev …

Effect of remote ischaemic preconditioning on myocardial injury in patients undergoing coronary artery bypass graft surgery: a randomised controlled trial

DJ Hausenloy, PK Mwamure, V Venugopal, J Harris… - The Lancet, 2007 - thelancet.com
Background Whether remote ischaemic preconditioning, an intervention in which brief
ischaemia of one tissue or organ protects remote organs from a sustained episode of …

Remote ischaemic preconditioning: underlying mechanisms and clinical application

DJ Hausenloy, DM Yellon - Cardiovascular research, 2008 - academic.oup.com
Remote ischaemic preconditioning (RIPC) represents a strategy for harnessing the body's
endogenous protective capabilities against the injury incurred by ischaemia and …

Genetic liability for prescription opioid use and risk of cardiovascular diseases: a multivariable Mendelian randomization study

J Cai, L He, H Wang, X Rong, M Chen, Q Shen, X Li… - …, 2022 - Wiley Online Library
Background and aims Observational studies have yielded conflicting results on the
association of prescription opioid use (POU) with the risk of cardiovascular diseases (CVD) …

Remote ischemic preconditioning: a novel protective method from ischemia reperfusion injury—a review

N Tapuria, Y Kumar, MM Habib, MA Amara… - Journal of Surgical …, 2008 - Elsevier
BACKGROUND: Restoration of blood supply to an organ after a critical period of ischemia
results in parenchymal injury and dysfunction of the organ referred to as reperfusion injury …

Transient Limb Ischemia Induces Remote Preconditioning and Remote Postconditioning in Humans by a KATP Channel–Dependent Mechanism

SP Loukogeorgakis, R Williams, AT Panagiotidou… - Circulation, 2007 - Am Heart Assoc
Background—Transient limb ischemia administered before a prolonged ischemic insult has
systemic protective effects against ischemia-reperfusion (IR) injury (remote ischemic …

Role of the parasympathetic nervous system in cardioprotection by remote hindlimb ischaemic preconditioning

M Donato, B Buchholz, M Rodríguez… - Experimental …, 2013 - Wiley Online Library
New findings• What is the central question of this study? Ischaemia–reperfusion of
peripheral tissues protects the heart from subsequent myocardial ischaemia–reperfusion …