Plasmepsins are a group of diverse aspartic proteases in the malaria parasite Plasmodium.
Their functions are strikingly multifaceted, ranging from hemoglobin degradation to secretory …

Malaria is a devastating parasitic disease affecting half of the world's population. The rapid
emergence of resistance against new antimalarial drugs, including artemisinin‐based …

Plasmepsins represent novel antimalarial drug targets. However, plasmepsin-based
antimalarial drug discovery efforts in the past 2 decades have generally suffered some …

Following erythrocyte invasion, malaria parasites export a catalogue of remodeling proteins
into the infected cell that enable parasite development in the human host. Export is …

Malaria is a life-threatening disease caused by Plasmodium parasites, which are transmitted
to humans through infected female Anopheles mosquitoes. Over the past few decades …

Background Plasmodium invasion of the mosquito midgut is a population bottleneck in the
parasite lifecycle. Interference with molecular mechanisms by which the ookinete invades …

Malaria is a life-threatening infectious disease caused by Plasmodium parasites.
Plasmepsins (proteolytic enzymes of the parasite) have been considered as promising …

Inhibition of aspartic cathepsin D-like peptidases (APDs) has been often discussed as an
antiparasite intervention strategy. APDs have been considered as virulence factors of …

Apicomplexan genomes encode multiple pepsin-family aspartyl proteases (APs) that
phylogenetically cluster to six independent clades (A to F). Such diversification has been …

Plasmepsin V is an aspartyl protease that plays a critical role in the export of proteins
bearing the Plasmodium export element (PEXEL) motif (RxLxQ/E/D) to the infected host …