Antiretroviral therapy is not curative. Given the challenges in providing lifelong therapy to a global population of more than 35 million people living with HIV, there is intense interest in …
RT Veenhuis, CM Abreu, PAG Costa, EA Ferreira… - Nature …, 2023 - nature.com
The development of persistent cellular reservoirs of latent human immunodeficiency virus (HIV) is a critical obstacle to viral eradication since viral rebound takes place once anti …
Brain microglia (MG) may serve as a human immunodeficiency virus 1 (HIV) reservoir and ignite rebound viremia following cessation of antiretroviral therapy (ART), but they have yet …
Y Ganor, F Real, A Sennepin, CA Dutertre… - Nature …, 2019 - nature.com
Human immunodeficiency virus type 1 (HIV-1) eradication is prevented by the establishment on infection of cellular HIV-1 reservoirs that are not fully characterized, especially in genital …
ME Wong, A Jaworowski, AC Hearps - Frontiers in immunology, 2019 - frontiersin.org
In people living with HIV (PLWH) who are failing or unable to access combination antiretroviral therapy (cART), monocytes and macrophages are important drivers of …
JB Honeycutt, WO Thayer, CE Baker, RM Ribeiro… - Nature medicine, 2017 - nature.com
Despite years of fully suppressive antiretroviral therapy (ART), HIV persists in its hosts and is never eradicated. One major barrier to eradication is that the virus infects multiple cell types …
L Zuliani-Alvarez, ML Govasli, J Rasaiyaah… - Nature …, 2022 - nature.com
Of the 13 known independent zoonoses of simian immunodeficiency viruses to humans, only one, leading to human immunodeficiency virus (HIV) type 1 (M) has become pandemic …
A Wahl, W Yao, B Liao, M Chateau, C Richardson… - Nature …, 2024 - nature.com
Abstract Germ-free (GF) mice, which are depleted of their resident microbiota, are the gold standard for exploring the role of the microbiome in health and disease; however, they are of …
JA White, FR Simonetti, S Beg… - Proceedings of the …, 2022 - National Acad Sciences
In persons living with HIV-1 (PLWH) who start antiretroviral therapy (ART), plasma virus decays in a biphasic fashion to below the detection limit. The first phase reflects the short …