Pathogenesis of HIV-1 and Mycobacterium tuberculosis co-infection

LCK Bell, M Noursadeghi - Nature Reviews Microbiology, 2018 - nature.com
Co-infection with Mycobacterium tuberculosis is the leading cause of death in individuals
infected with HIV-1. It has long been known that HIV-1 infection alters the course of M …

International AIDS Society global scientific strategy: towards an HIV cure 2016

SG Deeks, SR Lewin, AL Ross, J Ananworanich… - Nature medicine, 2016 - nature.com
Antiretroviral therapy is not curative. Given the challenges in providing lifelong therapy to a
global population of more than 35 million people living with HIV, there is intense interest in …

Monocyte-derived macrophages contain persistent latent HIV reservoirs

RT Veenhuis, CM Abreu, PAG Costa, EA Ferreira… - Nature …, 2023 - nature.com
The development of persistent cellular reservoirs of latent human immunodeficiency virus
(HIV) is a critical obstacle to viral eradication since viral rebound takes place once anti …

Brain microglia serve as a persistent HIV reservoir despite durable antiretroviral therapy

Y Tang, A Chaillon, S Gianella… - The Journal of …, 2023 - Am Soc Clin Investig
Brain microglia (MG) may serve as a human immunodeficiency virus 1 (HIV) reservoir and
ignite rebound viremia following cessation of antiretroviral therapy (ART), but they have yet …

HIV-1 reservoirs in urethral macrophages of patients under suppressive antiretroviral therapy

Y Ganor, F Real, A Sennepin, CA Dutertre… - Nature …, 2019 - nature.com
Human immunodeficiency virus type 1 (HIV-1) eradication is prevented by the establishment
on infection of cellular HIV-1 reservoirs that are not fully characterized, especially in genital …

The HIV reservoir in monocytes and macrophages

ME Wong, A Jaworowski, AC Hearps - Frontiers in immunology, 2019 - frontiersin.org
In people living with HIV (PLWH) who are failing or unable to access combination
antiretroviral therapy (cART), monocytes and macrophages are important drivers of …

HIV persistence in tissue macrophages of humanized myeloid-only mice during antiretroviral therapy

JB Honeycutt, WO Thayer, CE Baker, RM Ribeiro… - Nature medicine, 2017 - nature.com
Despite years of fully suppressive antiretroviral therapy (ART), HIV persists in its hosts and is
never eradicated. One major barrier to eradication is that the virus infects multiple cell types …

Evasion of cGAS and TRIM5 defines pandemic HIV

L Zuliani-Alvarez, ML Govasli, J Rasaiyaah… - Nature …, 2022 - nature.com
Of the 13 known independent zoonoses of simian immunodeficiency viruses to humans,
only one, leading to human immunodeficiency virus (HIV) type 1 (M) has become pandemic …

A germ-free humanized mouse model shows the contribution of resident microbiota to human-specific pathogen infection

A Wahl, W Yao, B Liao, M Chateau, C Richardson… - Nature …, 2024 - nature.com
Abstract Germ-free (GF) mice, which are depleted of their resident microbiota, are the gold
standard for exploring the role of the microbiome in health and disease; however, they are of …

Complex decay dynamics of HIV virions, intact and defective proviruses, and 2LTR circles following initiation of antiretroviral therapy

JA White, FR Simonetti, S Beg… - Proceedings of the …, 2022 - National Acad Sciences
In persons living with HIV-1 (PLWH) who start antiretroviral therapy (ART), plasma virus
decays in a biphasic fashion to below the detection limit. The first phase reflects the short …