Bone and skeletal muscle are integrated organs and their coupling has been considered
mainly a mechanical one in which bone serves as attachment site to muscle while muscle …

The development of the vertebrate skeleton reflects its evolutionary history. Cartilage
formation came before biomineralization and a head skeleton evolved before the formation …

Decades of work have identified the signaling pathways that regulate the differentiation of
chondrocytes during bone formation, from their initial induction from mesenchymal …

Skeletal elements have a diverse range of shapes and sizes specialized to their various
roles including protecting internal organs, locomotion, feeding, hearing, and vocalization …

Tendon is a crucial component of the musculoskeletal system. Tendons connect muscle to
bone and transmit forces to produce motion. Chronic and acute tendon injuries are very …

The proepicardial organ is an important transient structure that contributes cells to various
cardiac lineages. However, its contribution to the coronary endothelium has been disputed …

Connective tissues such as tendons or ligaments attach to bone across a multitissue
interface with spatial gradients in composition, structure, and mechanical properties. These …

The assembly of the musculoskeletal system requires the formation of an attachment unit
between a bone and a tendon. Tendons are often inserted into bone eminences …

Collagen is the most abundant secreted protein in vertebrates and persists throughout life
without renewal. The permanency of collagen networks contrasts with both the continued …

The Cre-loxP system is invaluable for spatial and temporal control of gene knockout,
knockin, and reporter expression in the mouse nervous system. However, we report varying …