Recombination is typically thought of as a symmetrical process resulting in large-scale
reciprocal genetic exchanges between homologous chromosomes. Recombination events …

The nuclear genomes of vertebrates are mosaics of isochores, very long stretches (≫
300kb) of DNA that are homogeneous in base composition and are compositionally …

Integrating classical knowledge of chromosome organisation with recent molecular and
functional findings, this book presents an up-to-date view of chromosome organisation and …

Vertebrate genomes are mosaics of isochores--namely, of long (> 300 kb), compositionally
homogeneous DNA segments that can be subdivided into a small number of families …

The term genome was first introduced by German botanist Hans Winkler in the early 19th
century to describe the eukaryotic chromosome. It gained considerable attention through the …

Several lines of evidence are presented which suggest that sequence G+ C content and
recombination frequency are related in mammals:(i) chromosome G+ C content is positively …

Previous investigations on the human genome determined:(i) the base compositions (GC
levels) and the relative amounts of its isochore families;(ii) the compositional correlations (ie …

In this paper, the relationship between codon usage and the physiological pattern of
expression of a gene is investigated while considering a dataset of 815 nuclear genes of …

Structural genomics is the study of the DNA of living organisms. Evolutionary genomics is
the study of the history of the genome. These subjects are closely interlinked. They are …

We have analyzed the correlation that exists between the GC levels of third and first or
second codon position for about 1400 human coding sequences. The linear relationship that …