Eph receptors and ephrins in cancer: bidirectional signalling and beyond

EB Pasquale - Nature Reviews Cancer, 2010 - nature.com
The Eph receptor tyrosine kinases and their ephrin ligands have intriguing expression
patterns in cancer cells and tumour blood vessels, which suggest important roles for their …

Eph receptor signaling and ephrins

EM Lisabeth, G Falivelli… - Cold Spring Harbor …, 2013 - cshperspectives.cshlp.org
The Eph receptors are the largest of the RTK families. Like other RTKs, they transduce
signals from the cell exterior to the interior through ligand-induced activation of their kinase …

Protein tyrosine phosphatases as potential therapeutic targets

R He, Z Yu, R Zhang, Z Zhang - Acta pharmacologica sinica, 2014 - nature.com
Protein tyrosine phosphorylation is a key regulatory process in virtually all aspects of cellular
functions. Dysregulation of protein tyrosine phosphorylation is a major cause of human …

Targeting EphA2 in cancer

T Xiao, Y Xiao, W Wang, YY Tang, Z Xiao… - Journal of hematology & …, 2020 - Springer
Eph receptors and the corresponding Eph receptor-interacting (ephrin) ligands jointly
constitute a critical cell signaling network that has multiple functions. The tyrosine kinase …

Eph receptor signalling casts a wide net on cell behaviour

EB Pasquale - Nature reviews Molecular cell biology, 2005 - nature.com
Eph receptor tyrosine kinases mould the behaviour of many cell types by binding membrane-
anchored ligands, ephrins, at sites of cell–cell contact. Eph signals affect both of the …

Oncogenic functions and therapeutic targeting of EphA2 in cancer

K Wilson, E Shiuan, DM Brantley-Sieders - Oncogene, 2021 - nature.com
More than 25 years of research and preclinical validation have defined EphA2 receptor
tyrosine kinase as a promising molecular target for clinical translation in cancer treatment …

Emerging strategies for EphA2 receptor targeting for cancer therapeutics

M Tandon, SV Vemula, SK Mittal - Expert opinion on therapeutic …, 2011 - Taylor & Francis
Importance of the field: High mortality rates with cancers warrant further development of
earlier diagnostics and better treatment strategies. Membrane-bound erythropoietin …

The EphA2 receptor and ephrinA1 ligand in solid tumors: function and therapeutic targeting

J Wykosky, W Debinski - Molecular Cancer Research, 2008 - AACR
The Eph receptor tyrosine kinases and ephrin ligands have been studied extensively for
their roles in developmental processes. In recent years, Eph receptors and ephrins have …

EphA2 expression is associated with aggressive features in ovarian carcinoma

PH Thaker, M Deavers, J Celestino, A Thornton… - Clinical Cancer …, 2004 - AACR
Purpose: EphA2 (epithelial cell kinase) is a transmembrane receptor tyrosine kinase that
has been implicated in oncogenesis. There are no published data regarding the role of …

The role of the Eph receptor family in tumorigenesis

M Anderton, E van der Meulen, MJ Blumenthal… - Cancers, 2021 - mdpi.com
Simple Summary The Eph receptor family is implicated in both tumour promotion and
suppression, depending on the tissue-specific context of available receptor interactions with …