Metamizole, a nonnarcotic analgesic, has been used to treat pain and fever for almost 90
years in some countries, while in others it is completely unknown or forgotten. It was …

Objective Treatment of inflammation and pain management is an important topic in the
welfare of pigs. It is very difficult for veterinary practitioners to choose the most appropriate …

The aim of the present study was to evaluate the antinociceptive potential of four novel
pyrazoline methyl ester compounds on chemical and thermal models of pain in mice. The …

The potential advantage of using combination therapy is that analgesia can be maximized
while minimizing the incidence of adverse effects. In order to assess a possible synergistic …

According to our previous study, ellagic acid has both dose-related central and peripheral
antinociceptive effect through the opioidergic and l-arginine-NO-cGMP-ATP sensitive K+ …

The efficacy of opioids in the treatment of chronic pain is limited; however, the adverse
effects they produce are considerable. N-palmitoylethanolamide (PEA), a bioactive lipid …

Oral antinociception of morphine, oxycodone and prodrug combinations in CD mice s nigkg--
Morphine (2.80 mg kg (1.95-4.02, 30 peak time--(Oxycodone 1.93 mgkg 133-2651) 30'peak …

L'administration intrapéritonéale de morphine, diclofénac, kétoprofène, meloxicam,
métamizol, paracétamol et piroxicam a induit une antinociception dépendante de la dose …

The combined administration of low doses of opiates with non-steroidal anti-inflammatory
drugs can produce additive or supra-additive analgesic effects while reducing unwanted …

This paper is the twenty-fifth consecutive installment of the annual review of research
concerning the endogenous opioid system, now spanning over a quarter-century of …