The spatiotemporal control of RNA polymerase II (Pol II)-mediated gene transcription is
tightly and intricately regulated. In addition, preservation of the integrity of the DNA template …

Nucleotide excision repair (NER) eliminates various structurally unrelated DNA lesions by a
multiwise'cut and patch'-type reaction. The global genome NER (GG-NER) subpathway …

The genome is constantly attacked by genotoxic insults. DNA damage has long been
established as a cause of cancer development through its mutagenic consequences …

DNA damage created by endogenous or exogenous genotoxic agents can exist in multiple
forms, and if allowed to persist, can promote genome instability and directly lead to various …

Genetic information is constantly being attacked by intrinsic and extrinsic damaging agents,
such as reactive oxygen species, atmospheric radiation, environmental chemicals, and …

Xeroderma pigmentosum (XP) is a rare, autosomal recessive disorder of DNA repair
characterized by sun sensitivity and UV radiation–induced skin and mucous membrane …

BACKGROUND: Inherited ichthyoses belong to a large, clinically and etiologically
heterogeneous group of mendelian disorders of cornification, typically involving the entire …

Histone H2AX phosphorylation on a serine four residues from the carboxyl terminus
(producing γH2AX) is a sensitive marker for DNA double-strand breaks (DSBs). DSBs may …

INTRODUCTION White matter in the human brain serves a critical role in organizing
distributed neural networks. Diffusion magnetic resonance imaging (dMRI) has enabled the …

Cockayne syndrome (CS) is a disorder characterized by a variety of clinical features
including cachectic dwarfism, severe neurological manifestations including microcephaly …