Atrial fibrillation (AF) is commonly associated with heart failure. A bidirectional relationship
exists between the two—AF exacerbates heart failure causing a significant increase in heart …

Calcium/calmodulin-dependent protein kinase II (CaMKII) is upregulated in diabetes and
significantly contributes to cardiac remodeling with increased risk of cardiac arrhythmias …

Abstract Store-operated Ca2+ entry (SOCE), a major Ca2+ signaling mechanism in non-
myocyte cells, has recently emerged as a component of Ca2+ signaling in cardiac myocytes …

Background The significance of autonomic dysfunction in premature ventricular contraction–
induced cardiomyopathy (PVC-CM) remain unknown. Objectives Utilizing a novel “dual …

During exercise or stress, the sympathetic system stimulates cardiac contractility via β‐
adrenergic receptor (β‐AR) activation, resulting in phosphorylation of the cardiac ryanodine …

The ryanodine receptor type 2 (RyR) is a key player in Ca 2+ handling during excitation-
contraction coupling. During each heartbeat, RyR channels are responsible for linking the …

Heart failure (HF) is a global pandemic with significant mortality and morbidity. Despite
current medications, 50% of individuals die within 5 years of diagnosis. Of these deaths, 30 …

The muscarinic acetylcholine receptor M3 (M3-mAChR) is involved in various physiological
and pathological processes. Owing to specific cardioprotective effects, M3-mAChR is an …

The role of luminal Ca regulation in Ca signaling refractoriness and cardiac arrhythmogenesis |
Journal of General Physiology | Rockefeller University Press Skip to Main Content …

Background The cGMP-dependent protein kinase G (PKG) phosphorylates the cardiac
ryanodine receptor (RyR2) in vitro. We aimed to determine whether modulation of …