The brain is the most complex organ of our body. Such a complexity spans from the single-
cell morphology up to the intricate connections that hundreds of thousands of neurons …

Inherent limitations of the traditional approaches to study brain function and disease, such
as rodent models and 2D cell culture platforms, have led to the development of 3D in vitro …

Investigation of neural circuit dynamics is crucial for deciphering the functional connections
among regions of the brain and understanding the mechanism of brain dysfunction. Despite …

Three-dimensional (3D) in vitro models have become increasingly popular as systems to
study cell–cell and cell–ECM interactions dependent on the spatial, mechanical, and …

Brain-on-Chip (BoC) biotechnology is emerging as a promising tool for biomedical and
pharmaceutical research applied to the neurosciences. At the convergence between lab-on …

Current research tools for preclinical drug development such as rodent models and two‐
dimensional immortalized monocultures have failed to serve as effective translational …

Background The emergence of three-dimensional (3D) cell culture in neural tissue
engineering has significantly elevated the complexity and relevance of in vitro systems. This …

The ability to create three-dimensional (3D) models of brain tissue from patient-derived cells,
would open new possibilities in studying the neuropathology of disorders such as epilepsy …

In vitro neuronal models have become an important tool to study healthy and diseased
neuronal circuits. The growing interest of neuroscientists to explore the dynamics of …

For 3D neural cultures durable hydrogels are required, which persist over a long
differentiation period and thus enable the maturation of neuronal networks (NN). Here, 3D …