Vascular endothelial growth factor receptor-2 (VEGFR-2) plays a critical role in cancer
angiogenesis. Inhibition of VEGFR-2 activity proved effective suppression of tumour …

VEGFR-2 is one of the most vital targets for the treatment of solid tumors. This work
represents synthetic approaches of new set of quinoxaline-based derivatives having …

Various heterocyclic systems based on natural and unnatural biologically active products
were synthesized by Brønsted acid-promoted cyclization. We have made an attempt to …

The oxidative amination of alkynes typically requires transition metal catalysts and strong
oxidants. Herein, we alternatively utilize DABCO as a sulfur-activating catalyst to achieve the …

There is an urgent need to design new anticancer agents that can prevent cancer cell
proliferation even with minimal side effects. Accordingly, two new series of 3 …

Fifteen quinazoline derivatives were designed and synthesized as DNA intercalators. The
cytotoxicity of the designed members was assessed against HCT-116 and HepG2 cancer …

This work describes the synthesis of eight different 6-nitro-1, 4-disubstituted-quinoxaline-2, 3‑
dione derivatives (4a-h). The starting material, 6-nitroquinoxaline-2, 3‑dione 3 was prepared …

In this paper, we report the successful synthesis of new 2-phenyl-3-substituted furo/thieno [2,
3-b] quinoxaline derivatives from 2-chloro-3-methoxyquinoxaline and 2-chloro-3 …

A series of quinoxaline-2-thiols and quinoxalines were prepared in moderate to good yields
from various phenacyl sulfoxides bearing 1-methyl-1H-tetrazole and o-arylenediamines. The …

Background: Quinoxaline is versatile ring systems which possesses a wide range of
physicochemical and biological activities. This heterocyclic nucleus is becoming an …