The heart must continuously pump blood to supply the body with oxygen and nutrients. To
maintain the high energy consumption required by this role, the heart is equipped with …

Dilated cardiomyopathy (DCM) is a leading cause of heart failure, sudden cardiac death and
heart transplant. DCM is inherited in approximately 50% of cases, in which the most frequent …

Titin-truncating variants (TTNtv) commonly cause dilated cardiomyopathy (DCM). TTNtv are
also encountered in∼ 1% of the general population, where they may be silent, perhaps …

Dilated cardiomyopathy (DCM) affects approximately 1 in 250 individuals and is the leading
indication for heart transplantation. DCM is often familial, and the most common genetic …

The heart's extraordinary metabolic flexibility allows it to adapt to normal changes in
physiology in order to preserve its function. Alterations in the metabolic profile of the heart …

Cardiovascular diseases are accompanied by disorders in the cardiac metabolism.
Furthermore, comorbidities often associated with cardiovascular disease can alter systemic …

The goal of this study was to measure arterial amino acid levels in patients with chronic
heart failure (CHF), and relate them to left ventricular function and disease severity. Amino …

Cardiac hypertrophy is closely linked to impaired fatty acid oxidation, but the molecular basis
of this link is unclear. Here, we investigated the loss of an obligate enzyme in mitochondrial …

The metabolic sources of energy for myocardial contractility include mainly free fatty acids
(FFA) for 95%, and in lesser amounts for 5% from glucose and minimal contributions from …

Cardiovascular complications are the leading cause of death in diabetic patients. Decades
of research has focused on altered gene expression, altered cellular signaling, and altered …