Energy deprivation is a frequent adverse event in tumors that is caused by mutations,
malperfusion, hypoxia, and nutrition deficit. The resulting bioenergetic stress leads to …

Hypoxia has been shown to increase the aggressiveness and severity of tumor progression.
Along with chronic and acute hypoxic regions, solid tumors contain regions of cycling …

Peroxisomes are involved in multiple metabolic processes, including fatty acid oxidation,
ether lipid synthesis, and reactive oxygen species (ROS) metabolism. Recent studies …

Simple Summary The tumoral microenvironment comprises cancer cells and surrounding
components, including immune and endothelial cells, along with the extracellular matrix. As …

There are a number of malignant tumors that metastasize into the lung as one of their most
common sites of dissemination. The successful infiltration of tumor cells into distant organs is …

Background Under conditions of hypoxia, cancer cells with hypoxia inducible factor-1α (HIF-
1α) from heterogeneous tumor cells show greater aggression and progression in an effort to …

Simple Summary Hypoxia is a common feature of lung cancers. Nonetheless, no guidelines
have been established to integrate hypoxia-associated biomarkers in patient management …

The microvasculature is a heterogeneous, dynamic and versatile component of the systemic
circulation, with a unique ability to locally self‐regulate and to respond to organ demand and …

There is no clear treatment guideline or individualized treatment plan for triple-negative
breast cancer (TNBC). The aim of this study was to investigate more effective targets for …

Organ-specific metastasis to secondary organs is dependent on the formation of a
supportive pre-metastatic niche. This tissue-specific microenvironmental response is thought …